Human GroES Recombinant Protein (RPPB5223)
- SKU:
- RPPB5223
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P61604
Description
| Product Name: | Human GroES Recombinant Protein |
| Product Code: | RPPB5223 |
| Size: | 20µg |
| Species: | Human |
| Target: | GroES |
| Synonyms: | CPN10, GROES, HSP10, HSPE1, Chaperonin-10, 10 kDa heat shock protein mitochondrial, 10 kDa chaperonin, Early-pregnancy factor, EPF. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The GroES protein contains 20mM Tris buffer pH-8 & 50mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MAGQAFRKFL PLFDRVLVER SAAETVTKGG IMLPEKSQGK VLQATVVAVG SGSKGKGGEI QPVSVKVGDK VLLPEYGGTK VVLDDKDYFL FRDGDILGKY VD |
HSP10 is part of the molecular chaperons, that are crucial for thir efficient folding of proteins in normal as well as stress conditions. GroES function is to bind to HSP60 in the presence of ATP, thus causing a change in the HSP60 conformation & enclosing the protein substrate within the complex. ATP hydrolysis by chaperonin-60 which destabilizes the HSP10-HSP60 complex, thereby allowing it to dissociate and secrete the substrate protein.GroES having the NCBI accession number of NP_002148 was purified by using conventional chromatography techniques.
Recombinant GroES produced in E.Coli is a single, non-glycosylated polypeptide chain containing 102 amino acids and having a molecular mass of 10 kDa.
| UniProt Protein Function: | HSPE1: Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. Belongs to the GroES chaperonin family. |
| UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 2q33.1 Cellular Component: membrane; mitochondrial matrix; mitochondrion Molecular Function:ATP binding; chaperone binding; protein binding; unfolded protein binding Biological Process: caspase activation; osteoblast differentiation; protein folding; response to unfolded protein |
| NCBI Summary: | This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011] |
| UniProt Code: | P61604 |
| NCBI GenInfo Identifier: | 47606335 |
| NCBI Gene ID: | 3336 |
| NCBI Accession: | P61604.2 |
| UniProt Secondary Accession: | P61604,O95421, Q04984, Q53X54, Q9UDH0, |
| UniProt Related Accession: | P61604 |
| Molecular Weight: | 10,932 Da |
| NCBI Full Name: | 10 kDa heat shock protein, mitochondrial |
| NCBI Synonym Full Names: | heat shock protein family E (Hsp10) member 1 |
| NCBI Official Symbol: | HSPE1�� |
| NCBI Official Synonym Symbols: | EPF; CPN10; GROES; HSP10�� |
| NCBI Protein Information: | 10 kDa heat shock protein, mitochondrial |
| UniProt Protein Name: | 10 kDa heat shock protein, mitochondrial |
| UniProt Synonym Protein Names: | 10 kDa chaperonin; Chaperonin 10; CPN10; Early-pregnancy factor; EPF |
| UniProt Gene Name: | HSPE1�� |
| UniProt Entry Name: | CH10_HUMAN |
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