Human GRO b Recombinant Protein (RPPB1147)
- SKU:
- RPPB1147
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P19875
- Research Area:
- Chemokines
Description
| Product Name: | Human GRO b Recombinant Protein |
| Product Code: | RPPB1147 |
| Size: | 10µg |
| Species: | Human |
| Target: | GRO b |
| Synonyms: | Macrophage inflammatory protein 2-alpha, MIP2-alpha, CXCL2, Growth- regulated protein beta, Gro-beta, chemokine (C-X-C motif) ligand 2, GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a, MGSA beta. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The Human CXCL2 protein solution contains 20mM Tris HCl�(pH 8.0). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAPLATELRC QCLQTLQGIH LKNIQSVKVK SPGPHCAQTE VIATLKNGQK ACLNPASPMV KKIIEKMLKNGKSN |
Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.
GRO-Beta Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 94 amino acids (35-107 a.a) and having a molecular mass of 10.1 kDa. The GRO-b is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. |
| NCBI Summary: | This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P19875 |
| NCBI GenInfo Identifier: | 127085 |
| NCBI Gene ID: | 2920 |
| NCBI Accession: | P19875.1 |
| UniProt Secondary Accession: | P19875,Q6FGD6, Q9UPB8, |
| UniProt Related Accession: | P19875 |
| Molecular Weight: | 11,389 Da |
| NCBI Full Name: | C-X-C motif chemokine 2 |
| NCBI Synonym Full Names: | C-X-C motif chemokine ligand 2 |
| NCBI Official Symbol: | CXCL2�� |
| NCBI Official Synonym Symbols: | GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a�� |
| NCBI Protein Information: | C-X-C motif chemokine 2 |
| UniProt Protein Name: | C-X-C motif chemokine 2 |
| UniProt Synonym Protein Names: | Growth-regulated protein beta; Gro-beta |
| Protein Family: | C-X-C motif chemokine |
| UniProt Gene Name: | CXCL2�� |
| UniProt Entry Name: | CXCL2_HUMAN |
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