Human GRAP2 Recombinant Protein (RPPB3640)
- SKU:
- RPPB3640
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O75791
Description
| Product Name: | Human GRAP2 Recombinant Protein |
| Product Code: | RPPB3640 |
| Size: | 10µg |
| Species: | Human |
| Target: | GRAP2 |
| Synonyms: | GRB2-related adaptor protein 2, GADS, GRBLG, GRID, GRBX, Grf40, Mona, Adapter protein GRID, Growth factor receptor-binding protein, Hematopoietic cell-associated adapter protein GRPL, GRB2L, P38, GRB-2-like protein, SH3-SH2-SH3 adapter Mona, GRAP-2, GRB2-related protein with insert domain, Growth Factor Receptor-bound protein 2-related adaptor protein 2, SH3-SH2-SH3 adaptor molecule, Protein GADS. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The GRAP2 protein solution (0.5mg/ml) is formulated in 20 mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT, 1mM EDTA and 30% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH�MEAVAKFDFT ASGEDELSFH TGDVLKILSN QEEWFKAELG SQEGYVPKNF IDIQFPKWFH EGLSRHQAEN LLMGKEVGFF IIRASQSSPG DFSISVRHED DVQHFKVMRD NKGNYFLWTE KFPSLNKLVD YYRTNSISRQ KQIFLRDRTR EDQGHRGNSL DRRSQGGPHL SGAVGEEIRP SMNRKLSDHP PTLPLQQHQH QPQPPQYAPA PQQLQQPPQQ RYLQHHHFHQ ERRGGSLDIN DGHCGTGLGS EMNAALMHRR HTDPVQLQAA GRVRWARALY DFEALEDDEL GFHSGEVVEV LDSSNPSWWT GRLHNKLGLF PANYVAPMTR |
GRAP2 belongs to the GRB2/Sem5/Drk family. GRAP2 is an adaptor-like protein has a part in leukocyte-specific protein-tyrosine kinase signaling. Similar to related family member, GRB2-related adaptor protein contains an SH2 domain flanked by two SH3 domains and it interacts with other proteins, for example GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains.
GRAP2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 350 amino acids (1-330.a.a) and having a molecular mass of 40.0kDa. GRAP2�is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GADS: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. Belongs to the GRB2/sem-5/DRK family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 22q13.2 Cellular Component: cytoplasm; cytosol; endosome; nucleoplasm; nucleus Molecular Function:protein binding; SH3/SH2 adaptor activity Biological Process: cell-cell signaling; innate immune response; positive regulation of signal transduction; Ras protein signal transduction; T cell costimulation; T cell receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014] |
| UniProt Code: | O75791 |
| NCBI GenInfo Identifier: | 6685489 |
| NCBI Gene ID: | 9402 |
| NCBI Accession: | O75791.1 |
| UniProt Secondary Accession: | O75791,O43726, Q9NRB7, B7Z8I3, |
| UniProt Related Accession: | O75791 |
| Molecular Weight: | 24,382 Da |
| NCBI Full Name: | GRB2-related adapter protein 2 |
| NCBI Synonym Full Names: | GRB2-related adaptor protein 2 |
| NCBI Official Symbol: | GRAP2�� |
| NCBI Official Synonym Symbols: | P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2�� |
| NCBI Protein Information: | GRB2-related adapter protein 2 |
| UniProt Protein Name: | GRB2-related adapter protein 2 |
| UniProt Synonym Protein Names: | Adapter protein GRID; GRB-2-like protein; GRB2L; GRBLG; GRBX; Grf40 adapter protein; Grf-40; Growth factor receptor-binding protein; Hematopoietic cell-associated adapter protein GrpL; P38; Protein GADS; SH3-SH2-SH3 adapter Mona |
| Protein Family: | GRB2-related adapter protein |
| UniProt Gene Name: | GRAP2�� |
| UniProt Entry Name: | GRAP2_HUMAN |
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