Human GPX2 Recombinant Protein (RPPB1744)
- SKU:
- RPPB1744
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P18283
- Research Area:
- Enzymes
Description
| Product Name: | Human GPX2 Recombinant Protein |
| Product Code: | RPPB1744 |
| Size: | 5µg |
| Species: | Human |
| Target: | GPX2 |
| Synonyms: | Glutathione peroxidase 2, GPx-2, GSHPx-2, Gastrointestinal glutathione peroxidase, Glutathione peroxidase-gastrointestinal, GPx-GI, GSHPx-GI, Glutathione peroxidase-related protein 2, GPRP-2, GPX2, GPRP, GI-GPx. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The GPX2 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH7.5), 40% glycerol, 0.15M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLC GTTTRDFTQL NELQCRFPRR LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT LVQKCEVNGQ NEHPVFAYLK DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV AWNFEKFLIG PEGEPFRRYS RTFPTINIEP DIKRLLKVAI |
Glutathione peroxidase 2 (GPX2) is a member of the glutathione peroxidase family, consisting of 8 known glutathione peroxidases (Gpx1-8) in humans. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. GPX2 may have a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. GPX2 is one of only a few proteins known in higher vertebrates to contain selenocysteine, which appears at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA.
GPX2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 210 amino acids (1-190) and having a molecular mass of 24.1kDa.GPX2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GPX2: Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors. Belongs to the glutathione peroxidase family. |
| UniProt Protein Details: | Protein type:Other Amino Acids Metabolism - glutathione; EC 1.11.1.9; Oxidoreductase; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 14q24.1 Cellular Component: cytoplasm; cytosol Molecular Function:electron carrier activity; glutathione peroxidase activity Biological Process: gene expression; response to reactive oxygen species; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The protein encoded by this locus contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012] |
| UniProt Code: | P18283 |
| NCBI GenInfo Identifier: | 32967607 |
| NCBI Gene ID: | 2877 |
| NCBI Accession: | NP_002074.2 |
| UniProt Secondary Accession: | P18283,Q6PJ52, Q8WWI7, Q9NRP9, |
| UniProt Related Accession: | P18283 |
| Molecular Weight: | 21,954 Da |
| NCBI Full Name: | glutathione peroxidase 2 |
| NCBI Synonym Full Names: | glutathione peroxidase 2 |
| NCBI Official Symbol: | GPX2�� |
| NCBI Official Synonym Symbols: | GPRP; GPx-2; GI-GPx; GPRP-2; GPx-GI; GSHPx-2; GSHPX-GI�� |
| NCBI Protein Information: | glutathione peroxidase 2 |
| UniProt Protein Name: | Glutathione peroxidase 2 |
| UniProt Synonym Protein Names: | Gastrointestinal glutathione peroxidase; Glutathione peroxidase-gastrointestinal; GPx-GI; GSHPx-GI; Glutathione peroxidase-related protein 2; GPRP-2 |
| Protein Family: | Glutathione peroxidase |
| UniProt Gene Name: | GPX2�� |
| UniProt Entry Name: | GPX2_HUMAN |
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