Human GPN1 Recombinant Protein (RPPB3636)
- SKU:
- RPPB3636
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9HCN4
Description
| Product Name: | Human GPN1 Recombinant Protein |
| Product Code: | RPPB3636 |
| Size: | 25µg |
| Species: | Human |
| Target: | GPN1 |
| Synonyms: | GPN-loop GTPase 1, XPA binding protein 1 GTPase, RNA polymerase II associated protein 4, MBD2-interacting protein, MBDin, ATP(GTP)-binding protein, XAB1, ATPBD1A, NTPBP, RPAP4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The GPN1 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 50mM NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMAASAA AAELQASGGP RHPVCLLVLG MAGSGKTTFV QRLTGHLHAQ GTPPYVINLD PAVHEVPFPA NIDIRDTVKY KEVMKQYGLG PNGGIVTSLN LFATRFDQVM KFIEKAQNMS KYVLIDTPGQ IEVFTWSASG TIITEALASS FPTVVIYVMD TSRSTNPVTF MSNMLYACSI LYKTKLPFIV VMNKTDIIDH SFAVEWMQDF EAFQDALNQE TTYVSNLTRS MSLVLDEFYS SLRVVGVSAV LGTGLDELFV QVTSAAEEYE REYRPEYERL KKSLANAESQ QQREQLERLR KDMGSVALDA GTAKDSLSPV LHPSDLILTR GTLDEEDEEA DSDTDDIDHR VTEESHEEPA FQNFMQESMA QYWKRNNK |
GPN-loop GTPase 1 (GPN1) is a member of the GPN-loop GTPase family. GPN1 is a guanosine triphosphatase enzyme which has a role in DNA repair and may function in activation of transcription. Small GTPases, which share a biochemical mechanism, act as binary molecular switches and function in the cell is nucleocytoplasmic transport of both proteins and RNA. In addition, GPN1 establishs an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, proposing that it is essential to connect RNA polymerase II to regulators of protein complex formation. GPN1 may also be involved in nuclear localization of XPA.
GPN1 Human Recombinant produced in E. coli is a single polypeptide chain containing 398 amino acids (1-374) and having a molecular mass of 44.3 kDa.GPN1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GPN1: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA. Belongs to the GPN-loop GTPase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Hydrolase Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: cytoplasm; nucleus Molecular Function:GTPase activity; protein binding; GTP binding Biological Process: metabolic process |
| UniProt Code: | Q9HCN4 |
| NCBI GenInfo Identifier: | 34925430 |
| NCBI Gene ID: | |
| NCBI Accession: | Q9HCN4.1 |
| Molecular Weight: | |
| NCBI Full Name: | GPN-loop GTPase 1 |
| UniProt Protein Name: | GPN-loop GTPase 1 |
| UniProt Synonym Protein Names: | MBD2-interacting protein; XPA-binding protein 1 |
| UniProt Gene Name: | GPN1�� |
| UniProt Entry Name: | GPN1_HUMAN |
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