Human GOSR2 Recombinant Protein (RPPB3630)
- SKU:
- RPPB3630
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O14653
Description
| Product Name: | Human GOSR2 Recombinant Protein |
| Product Code: | RPPB3630 |
| Size: | 10µg |
| Species: | Human |
| Target: | GOSR2 |
| Synonyms: | Bos1, EPM6, GS27, Membrin, Golgi SNAP receptor complex member 2, 27 kDa Golgi SNARE protein, GOSR2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | GOSR2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDPLFQQ THKQVHEIQS CMGRLETADK QSVHIVENEI QASIDQIFSR LERLEILSSK EPPNKRQNAR LRVDQLKYDV QHLQTALRNF QHRRHAREQQ ERQREELLSR TFTTNDSDTT IPMDESLQFN SSLQKVHNGM DDLILDGHNI LDGLRTQRLT LKGTQKKILD IANMLGLSNT VMRLIEKRAF QDK |
Golgi SNAP receptor complex member 2 isoform A (GOSR2) is a part of the SNARE Protein family which consists of important trafficking proteins between the endoplasmic reticulum and the Golgi and between Golgi subcompartments. GOSR2 is located near a locus implicated in familial essential hypertension, indicating that it is a potential candidate gene for this disease. GOSR2 exists as cytoplasmically oriented integral membrane proteins.
GOSR2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 213 amino acids (1-190a.a) and having a molecular mass of 24.6kDa. GOSR2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GOSR2: Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network. Defects in GOSR2 are the cause of progressive myoclonic epilepsy type 6 (EPM6). A neurologic disorder characterized by onset of ataxia in the first years of life, followed by action myoclonus and seizures later in childhood, and loss of independent ambulation in the second decade. Cognition is not usually affected, although mild memory difficulties may occur in the third decade. Belongs to the GOSR2 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q21 Cellular Component: Golgi membrane; SNARE complex; Golgi apparatus; endoplasmic reticulum membrane; Golgi stack; membrane; late endosome membrane; integral to membrane Molecular Function:SNAP receptor activity; SNARE binding; transporter activity Biological Process: intra-Golgi vesicle-mediated transport; ER to Golgi vesicle-mediated transport; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; unfolded protein response; Golgi to vacuole transport; vesicle fusion with Golgi apparatus; protein targeting to vacuole; retrograde transport, endosome to Golgi Disease: Epilepsy, Progressive Myoclonic 6 |
| NCBI Summary: | This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14653 |
| NCBI GenInfo Identifier: | 22654242 |
| NCBI Gene ID: | 9570 |
| NCBI Accession: | O14653.2 |
| UniProt Secondary Accession: | O14653,Q8N4B8, Q96DA5, Q9BZZ4, D3DXJ5, D3DXJ6, |
| UniProt Related Accession: | O14653 |
| Molecular Weight: | 212 |
| NCBI Full Name: | Golgi SNAP receptor complex member 2 |
| NCBI Synonym Full Names: | golgi SNAP receptor complex member 2 |
| NCBI Official Symbol: | GOSR2�� |
| NCBI Official Synonym Symbols: | Bos1; EPM6; GS27�� |
| NCBI Protein Information: | Golgi SNAP receptor complex member 2; membrin; 27 kDa Golgi SNARE protein |
| UniProt Protein Name: | Golgi SNAP receptor complex member 2 |
| UniProt Synonym Protein Names: | 27 kDa Golgi SNARE protein; Membrin |
| Protein Family: | Golgi SNAP receptor complex |
| UniProt Gene Name: | GOSR2�� |
| UniProt Entry Name: | GOSR2_HUMAN |
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