Human GNB1 Recombinant Protein (RPPB3618)
- SKU:
- RPPB3618
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P62873
Description
| Product Name: | Human GNB1 Recombinant Protein |
| Product Code: | RPPB3618 |
| Size: | 10µg |
| Species: | Human |
| Target: | GNB1 |
| Synonyms: | Guanine Nucleotide Binding Protein (G Protein) Beta Polypeptide 1, Transducin Beta Chain 1, GNB1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The GNB1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSELDQL RQEAEQLKNQ IRDARKACAD ATLSQITNNI DPVGRIQMRT RRTLRGHLAK IYAMHWGTDS RLLVSASQDG KLIIWDSYTT NKVHAIPLRS SWVMTCAYAP SGNYVACGGL DNICSIYNLK TREGNVRVSR ELAGHTGYLS CCRFLDDNQI VTSSGDTTCA LWDIETGQQT TTFTGHTGDV MSLSLAPDTR LFVSGACDAS AKLWDVREGM CRQTFTGHES DINAICFFPN GNAFATGSDD ATCRLFDLRA DQELMTYSHD NIICGITSVS FSKSGRLLLA GYDDFNCNVW DALKADRAGV LAGHDNRVSC LGVTDDGMAV ATGSWDSFLK IWN |
Heterotrimeric guanine nucleotide-binding proteins (G proteins) which integrate signals between receptors and effector proteins, are comprised of an alpha, a beta and a gamma subunit. The alpha, beta and gamma subunits are encoded by families of related genes. GNB1 encodes a beta subunit. Beta subunits are vital regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. G proteins are involved as a modulator or transducer in numerous transmembrane signaling systems. The beta and gamma chains are necessary for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
GNB1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 363 amino acids (1-340) and having a molecular mass of 39.8 kDa.GNB1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | G-beta 1: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the WD repeat G protein beta family. |
| UniProt Protein Details: | Protein type:G protein, heterotrimeric beta; G protein, heterotrimeric; G protein Chromosomal Location of Human Ortholog: 1p36.33 Cellular Component: cytosol; heterotrimeric G-protein complex; intracellular; lysosomal membrane; membrane; plasma membrane Molecular Function:GTPase activity; GTPase binding; protein binding; protein complex binding Biological Process: acetylcholine receptor signaling, muscarinic pathway; dopamine receptor, adenylate cyclase activating pathway; platelet activation; protein folding; Ras protein signal transduction; rhodopsin mediated signaling; signal transduction; Wnt receptor signaling pathway, calcium modulating pathway |
| NCBI Summary: | Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | P62873 |
| NCBI GenInfo Identifier: | 51317302 |
| NCBI Gene ID: | 2782 |
| NCBI Accession: | P62873.3 |
| UniProt Secondary Accession: | P62873,P04697, P04901, Q1RMY8, B1AJZ7, |
| UniProt Related Accession: | P62873 |
| Molecular Weight: | 36,298 Da |
| NCBI Full Name: | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 |
| NCBI Synonym Full Names: | G protein subunit beta 1 |
| NCBI Official Symbol: | GNB1�� |
| NCBI Official Synonym Symbols: | MRD42�� |
| NCBI Protein Information: | guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 |
| UniProt Protein Name: | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 |
| UniProt Synonym Protein Names: | Transducin beta chain 1 |
| UniProt Gene Name: | GNB1�� |
| UniProt Entry Name: | GBB1_HUMAN |
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