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Human GMPR2 Recombinant Protein (RPPB1715)

SKU:
RPPB1715
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9P2T1
Research Area:
Enzymes
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Description

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Product Name:Human GMPR2 Recombinant Protein
Product Code:RPPB1715
Size:10µg
Species:Human
Target:GMPR2
Synonyms:GMP reductase 2, Guanosine 5''-monophosphate oxidoreductase 2.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:GMPR2 1mg/ml solution contains 20mM Tris pH-8, 1mM DTT and 10% glycerol.
Stability:GMPR2 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFSFRN SKQTYSGVPI IAANMDTVGT FEMAKVLCKFSLFTAVHKHY SLVQWQEFAG QNPDCLEHLA ASSGTGSSDF EQLEQILEAI PQVKYICLDV ANGYSEHFVE FVKDVRKRFP QHTIMAGNVV TGEMVEELIL SGADIIKVGI GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM LGGMLAGHSESGGELIERDG KKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD VEHTIRDILG GIRSTCTYVG AAKLKELSRR TTFIRVTQQV NPIFSEAC

GMPR2 is the single known metabolic step by which guanine nucleotides can be transformed to the pivotal precursor of both adenine and guanine nucleotides. GMPR2 catalyzes the permanent NADPH-dependent reductive deamination of GMP to IMP, and is involved in re-utilization of free intracellular bases and purine nucleosides.

GMPR2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 368 amino acids (1-348 a.a.) and having a molecular mass of 40 kDa. GMPR2 is fused to a 20 amino acid His-tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:GMPR2: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation. Belongs to the IMPDH/GMPR family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.7.1.7; Nucleotide Metabolism - purine; OxidoreductaseChromosomal Location of Human Ortholog: 14q12Cellular Component: cytosolMolecular Function: GMP reductase activity; metal ion bindingBiological Process: nucleobase, nucleoside and nucleotide metabolic process; purine salvage; GMP metabolic process; purine base metabolic process
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9P2T1
NCBI GenInfo Identifier:50541952
NCBI Gene ID:51292
NCBI Accession:NP_001002000.1
UniProt Secondary Accession:Q9P2T1,Q567T0, Q6IAJ8, Q86T14, D3DS66
UniProt Related Accession:Q9P2T1
Molecular Weight:34,597 Da
NCBI Full Name:GMP reductase 2 isoform 2
NCBI Synonym Full Names:guanosine monophosphate reductase 2
NCBI Official Symbol:GMPR2��
NCBI Official Synonym Symbols:
NCBI Protein Information:GMP reductase 2; guanosine 5'-monophosphate oxidoreductase 2; guanosine monophosphate reductase isolog
UniProt Protein Name:GMP reductase 2
UniProt Synonym Protein Names:Guanosine 5'-monophosphate oxidoreductase 2; Guanosine monophosphate reductase 2
Protein Family:GMP reductase
UniProt Gene Name:GMPR2��
UniProt Entry Name:GMPR2_HUMAN

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