Human GMPR Recombinant Protein (RPPB1714)
- SKU:
- RPPB1714
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P36959
- Research Area:
- Enzymes
Description
| Product Name: | Human GMPR Recombinant Protein |
| Product Code: | RPPB1714 |
| Size: | 20µg |
| Species: | Human |
| Target: | GMPR |
| Synonyms: | GMP reductase 1, Guanosine 5'-monophosphate oxidoreductase 1, Guanosine monophosphate reductase 1, GMPR, GMPR1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear colorless solution. |
| Formulation: | The GMPR solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.15M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPRIDADLKL DFKDVLLRPK RSSLKSRAEV DLERTFTFRN SKQTYSGIPI IVANMDTVGT FEMAAVMSQH SMFTAIHKHY SLDDWKLFAT NHPECLQNVA VSSGSGQNDL EKMTSILEAV PQVKFICLDV ANGYSEHFVE FVKLVRAKFP EHTIMAGNVV TGEMVEELIL SGADIIKVGV GPGSVCTTRT KTGVGYPQLS AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM LGGMFSGHTE CAGEVIERNG RKLKLFYGMS SDTAMNKHAG GVAEYRASEG KTVEVPYKGD VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFS |
Guanosine monophosphate reductase (GMPR) catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. GMPR acts in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in upholding the intracellular balance of A and G nucleotides. In addition, the GMPR protein functions in the re-utilization of free intracellular bases and purine nucleosides.
GMPR Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 365 amino acids (1-345) and having a molecular mass of 39.5kDa.GMPR is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GMPR: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; EC 1.7.1.7; Oxidoreductase Chromosomal Location of Human Ortholog: 6p23 Cellular Component: cytosol Molecular Function:GMP reductase activity; metal ion binding Biological Process: nucleobase, nucleoside and nucleotide metabolic process; nucleotide metabolic process; response to cold; purine base metabolic process; purine salvage |
| NCBI Summary: | This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.[provided by RefSeq, Oct 2009] |
| UniProt Code: | P36959 |
| NCBI GenInfo Identifier: | 544455 |
| NCBI Gene ID: | 2766 |
| NCBI Accession: | P36959.1 |
| UniProt Secondary Accession: | P36959,Q96HQ6, |
| UniProt Related Accession: | P36959 |
| Molecular Weight: | 37,419 Da |
| NCBI Full Name: | GMP reductase 1 |
| NCBI Synonym Full Names: | guanosine monophosphate reductase |
| NCBI Official Symbol: | GMPR�� |
| NCBI Official Synonym Symbols: | GMPR1�� |
| NCBI Protein Information: | GMP reductase 1; guanine monophosphate reductase; guanosine 5'-monophosphate oxidoreductase 1; guanosine monophosphate reductase 1 |
| UniProt Protein Name: | GMP reductase 1 |
| UniProt Synonym Protein Names: | Guanosine 5'-monophosphate oxidoreductase 1; Guanosine monophosphate reductase 1 |
| Protein Family: | GMP reductase |
| UniProt Gene Name: | GMPR�� |
| UniProt Entry Name: | GMPR1_HUMAN |
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