Human GM CSF Recombinant Protein (RPPB0356)
- SKU:
- RPPB0356
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P04141
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human GM CSF Recombinant Protein |
| Product Code: | RPPB0356 |
| Size: | 20µg |
| Species: | Human |
| Target: | GM CSF |
| Synonyms: | CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha, Molgramostin, Sargramostim, MGC131935, MGC138897. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | Granulocyte Macrophage Colony Stimulating Factor-His is supplied in 20mM Tris HCl (pH 8) and 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Granulocyte Macrophage Colony Stimulating Factor is a potent species-specific growth factor produced by a variety of cell types including T cells, B cells, macrophages, mast cells and endothelial cells. GM-CSF is produced in response to cytokine or immune stimulation and has been shown to stimulate the proliferation, maturation and function of hematopoietic cells.
GMCSF Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 127 amino acids fragment (18-144) and having a molecular mass of 18.98kDa with an amino-terminal hexahistidine tag. GM-CSF Human Recombinant His is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cytokine Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: extracellular space; extracellular region Molecular Function:protein binding; growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; positive regulation of cell proliferation; myeloid dendritic cell differentiation; immune response; positive regulation of DNA replication |
| NCBI Summary: | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P04141 |
| NCBI GenInfo Identifier: | 117561 |
| NCBI Gene ID: | 1437 |
| NCBI Accession: | P04141.1 |
| UniProt Secondary Accession: | P04141,Q14CE8, Q2VPI8, Q8NFI6, |
| UniProt Related Accession: | P04141 |
| Molecular Weight: | 16,295 Da |
| NCBI Full Name: | Granulocyte-macrophage colony-stimulating factor |
| NCBI Synonym Full Names: | colony stimulating factor 2 (granulocyte-macrophage) |
| NCBI Official Symbol: | CSF2�� |
| NCBI Official Synonym Symbols: | GMCSF�� |
| NCBI Protein Information: | granulocyte-macrophage colony-stimulating factor; CSF; molgramostin; sargramostim |
| UniProt Protein Name: | Granulocyte-macrophage colony-stimulating factor |
| UniProt Synonym Protein Names: | Colony-stimulating factor; CSF; Molgramostin; Sargramostim |
| Protein Family: | Granulocyte-macrophage colony-stimulating factor |
| UniProt Gene Name: | CSF2�� |
| UniProt Entry Name: | CSF2_HUMAN |
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