Human GM-CSF Polyclonal Antibody (CAB22109)
- SKU:
- CAB22109
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Human GM-CSF Polyclonal Antibody |
| SKU: | CAB22109 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-144 of human Human GM-CSF (NP_000749.2). |
| Sequence: | APAR SPSP STQP WEHV NAIQ EARR LLNL SRDT AAEM NETV EVIS EMFD LQEP TCLQ TRLE LYKQ GLRG SLTK LKGP LTMM ASHY KQHC PPTP ETSC ATQI ITFE SFKE NLKD FLLV IPFD CWEP VQE |
| Tested Applications: | WB ELISA |
| Recommended Dilution: | WB,1:500 - 1:1000 |
| Synonyms: | CSF; GMCSF; Human GM-CSF |
| Positive Sample: | HuT 78 |
| Conjugate: | Unconjugated |
| Cellular Localization: | extracellular region, extracellular space |
| Calculated MW: | 16kDa |
| Observed MW: | 22kDa |
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis.
| Purification Method: | Affinity purification |
| Gene ID: | 1437 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |
 | Western blot analysis of HuT 78, using Human GM-CSF Rabbit pAb (CAB22109) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s. |
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