The Human GM-CSF Polyclonal Antibody is a valuable tool for researchers studying Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), a cytokine that plays a crucial role in regulating the immune response. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in applications such as Western blot and immunohistochemistry.GM-CSF is involved in the differentiation and function of various immune cells, including granulocytes, macrophages, and dendritic cells, making it a key player in both innate and adaptive immunity.
Dysregulation of GM-CSF signaling has been implicated in a variety of immune-related disorders, including autoimmune diseases and cancer.With the Human GM-CSF Polyclonal Antibody, researchers can accurately detect and analyze GM-CSF expression in a variety of biological samples, providing valuable insights into the role of this cytokine in health and disease. This antibody is a valuable tool for studies in immunology, oncology, and inflammation research, offering new avenues for therapeutic development and understanding the complexities of the immune system.
Product Name:
Human GM-CSF Polyclonal Antibody
SKU:
CAB22109
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 18-144 of human Human GM-CSF (NP_000749.2).
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis.
Purification Method:
Affinity purification
Gene ID:
1437
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of HuT 78, using Human GM-CSF Rabbit pAb (CAB22109) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
