Human GLRX1 Recombinant Protein (RPPB1698)
- SKU:
- RPPB1698
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P35754
- Research Area:
- Enzymes
Description
| Product Name: | Human GLRX1 Recombinant Protein |
| Product Code: | RPPB1698 |
| Size: | 50µg |
| Species: | Human |
| Target: | GLRX1 |
| Synonyms: | Thioltransferase, GRX, GLRX1, GRX1, GRX-1, GLRX-1, Glutathione-dependent oxidoreductase 1, Glutaredoxin-1, Thioltransferase-1, TTase-1, GLRX, MGC117407. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear colorless solution. |
| Formulation: | Glutaredoxin solution (1mg/ml) contains 20mM Tris-HCl pH-8, 1mM DTT & 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MAQEFVNCKI QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK QIGALQ |
GLRX1 has a glutathione-disulfide oxidoreductase activity in the presence of nadph and glutathione reductase. reduces low molecular weight disulfides and proteins.Glutaredoxin is a glutathione (GSH)-dependent hydrogen donor for ribonucleotide reductase and also catalyzes glutathione-disulfide oxidoreduction reactions in the presence of NADPH and glutathione reductase. GLRX1 is multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage.
Glutaredoxin Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 106 amino acids having a molecular mass of 11.7 kDa.
| UniProt Protein Function: | GLRX1: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Belongs to the glutaredoxin family. |
| UniProt Protein Details: | Protein type:Oxidoreductase Chromosomal Location of Human Ortholog: 5q14 Cellular Component: mitochondrion; nucleus; cytosol Molecular Function:electron carrier activity; protein N-terminus binding; glutathione disulfide oxidoreductase activity Biological Process: cell redox homeostasis; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; positive regulation of membrane potential |
| NCBI Summary: | This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P35754 |
| NCBI GenInfo Identifier: | 1346143 |
| NCBI Gene ID: | 2745 |
| NCBI Accession: | P35754.2 |
| UniProt Secondary Accession: | P35754,Q3KQS1, Q6ICT1, B2R4L2, |
| UniProt Related Accession: | P35754 |
| Molecular Weight: | 106 |
| NCBI Full Name: | Glutaredoxin-1 |
| NCBI Synonym Full Names: | glutaredoxin (thioltransferase) |
| NCBI Official Symbol: | GLRX�� |
| NCBI Official Synonym Symbols: | GRX; GRX1�� |
| NCBI Protein Information: | glutaredoxin-1; TTase-1; thioltransferase-1 |
| UniProt Protein Name: | Glutaredoxin-1 |
| UniProt Synonym Protein Names: | Thioltransferase-1; TTase-1 |
| UniProt Gene Name: | GLRX�� |
| UniProt Entry Name: | GLRX1_HUMAN |
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