Human GGCT Recombinant Protein (RPPB1687)
- SKU:
- RPPB1687
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O75223
- Research Area:
- Enzymes
Description
| Product Name: | Human GGCT Recombinant Protein |
| Product Code: | RPPB1687 |
| Size: | 20µg |
| Species: | Human |
| Target: | GGCT |
| Synonyms: | Gamma-Glutamylcyclotransferase, CRF21, C7orf24, MGC3077, Cytochrome c-releasing factor 21, GCTG, Ggc, Chromosome 7 open reading frame 24, FLJ11717, EC 2.3.2.4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The GGCT protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSHMANSGCKDVT GPDEESFLYF AYGSNLLTER IHLRNPSAAF FCVARLQDFK LDFGNSQGKT SQTWHGGIAT IFQSPGDEVW GVVWKMNKSN LNSLDEQEGV KSGMYVVIEV KVATQEGKEI TCRSYLMTNY ESAPPSPQYK KIICMGAKEN GLPLEYQEKL KAIEPNDYTG KVSEEIEDII KKGETQTL |
GGCT is a member of the family of transferases, specifically the aminoacyltransferases. GGCT protein catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and takes an important part in glutathione homeostasis. GGCT induces release of cytochrome c from mitochondria with resultant induction of apoptosis.
GGCT produced in E.Coli is a single, non-glycosylated polypeptide chain containing 208 amino acids (1-188a.a.) and having a molecular mass of 23.2kDa.GGCT is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GGCT: Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Belongs to the gamma-glutamylcyclotransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.3.2.4; Transferase; Apoptosis; Other Amino Acids Metabolism - glutathione Chromosomal Location of Human Ortholog: 7p15-p14 Cellular Component: cytosol Molecular Function:gamma-glutamylcyclotransferase activity; protein homodimerization activity Biological Process: glutathione biosynthetic process; release of cytochrome c from mitochondria |
| NCBI Summary: | The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | O75223 |
| NCBI GenInfo Identifier: | 34222503 |
| NCBI Gene ID: | 79017 |
| NCBI Accession: | O75223.1 |
| UniProt Secondary Accession: | O75223,Q9BS37, B2RDN0, B8ZZN4, B8ZZR8, |
| UniProt Related Accession: | O75223 |
| Molecular Weight: | 19,092 Da |
| NCBI Full Name: | Gamma-glutamylcyclotransferase |
| NCBI Synonym Full Names: | gamma-glutamylcyclotransferase |
| NCBI Official Symbol: | GGCT�� |
| NCBI Official Synonym Symbols: | GGC; GCTG; CRF21; C7orf24�� |
| NCBI Protein Information: | gamma-glutamylcyclotransferase |
| UniProt Protein Name: | Gamma-glutamylcyclotransferase |
| UniProt Synonym Protein Names: | Cytochrome c-releasing factor 21 |
| Protein Family: | Gamma-glutamylcyclotransferase |
| UniProt Gene Name: | GGCT�� |
| UniProt Entry Name: | GGCT_HUMAN |
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