Human GEMIN6 Recombinant Protein (RPPB3587)
- SKU:
- RPPB3587
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8WXD5
Description
| Product Name: | Human GEMIN6 Recombinant Protein |
| Product Code: | RPPB3587 |
| Size: | 10µg |
| Species: | Human |
| Target: | GEMIN6 |
| Synonyms: | Gem-associated protein 6, Gemin-6, SIP2, GEMIN6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | GEMIN6 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSEWMKK GPLEWQDYIY KEVRVTASEK NEYKGWVLTT DPVSANIVLV NFLEDGSMSV TGIMGHAVQT VETMNEGDHR VREKLMHLFT SGDCKAYSPE DLEERKNSLK KWLEKNHIPI TEQGDAPRTL CVAGVLTIDP PYGPENCSSS NEIILSRVQD LIEGHLTASQ |
Gem-Associated Protein 6 (GEMIN6) is a member of a large macromolecular complex, localized to both the cytoplasm and the nucleus, which takes part in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). SMN, GEMIN2, GEMIN3, GEMIN4, and GEMIN5 are additional members of this complex.
GEMIN6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 190 amino acids (1-167a.a) and having a molecular mass of 21.9kDa. GEMIN6 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GEMIN6: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. |
| UniProt Protein Details: | Protein type:RNA splicing Chromosomal Location of Human Ortholog: 2p22.1 Cellular Component: cytoplasm; cytosol; nuclear body; nucleoplasm; SMN complex Molecular Function:protein binding Biological Process: nuclear import; nuclear mRNA splicing, via spliceosome; spliceosomal snRNP biogenesis |
| NCBI Summary: | GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002] |
| UniProt Code: | Q8WXD5 |
| NCBI GenInfo Identifier: | 34921901 |
| NCBI Gene ID: | 79833 |
| NCBI Accession: | Q8WXD5.1 |
| UniProt Secondary Accession: | Q8WXD5,Q53SI5, Q8WVB4, Q9H5G6, B2RDP8, |
| UniProt Related Accession: | Q8WXD5 |
| Molecular Weight: | 19kDa |
| NCBI Full Name: | Gem-associated protein 6 |
| NCBI Synonym Full Names: | gem nuclear organelle associated protein 6 |
| NCBI Official Symbol: | GEMIN6�� |
| NCBI Protein Information: | gem-associated protein 6 |
| UniProt Protein Name: | Gem-associated protein 6 |
| UniProt Synonym Protein Names: | SIP2 |
| Protein Family: | Gem-associated protein |
| UniProt Gene Name: | GEMIN6�� |
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