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Human GDF11 Recombinant Protein (RPPB0311)

SKU:
RPPB0311
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95390
Research Area:
Cytokines
$371
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Description

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Product Name:Human GDF11 Recombinant Protein
Product Code:RPPB0311
Size:20µg
Species:Human
Target:GDF11
Synonyms:GrowthDifferentiation Factor 11, BMP11, Bone Morphogenetic Protein 11, BMP-11, GDF-11,Growth/Differentiation Factor 11, Growth/differentiation factor 11.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:GDF11 protein solution (1mg/ml) containing 20mM Tris-HCl(pH8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHHSSGLVPRGSH MGSNLGLDCDEHSSESRCCR YPLTVDFEAF GWDWIIAPKR YKANYCSGQC EYMFMQKYPH THLVQQANPR GSAGPCCTPTKMSPINMLYF NDKQQIIYGK IPGMVVDRCG CS

GDF-11 belongs to the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. GDF-11 is a central developmental factor which controls muscular and neural development. In adults, GDF-11 encourages cardiac hypertrophy reverse by the revival of cardiomyocytes.

GDF11 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 132 amino acids (299-407a.a) and having amolecular mass of 14.8kDa.GDF11 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: extracellular space; intracellular membrane-bound organelle; nucleoplasm; protein complex

Molecular Function:cytokine activity; growth factor activity; transforming growth factor beta receptor binding

Biological Process: camera-type eye morphogenesis; cell development; cell maturation; growth; mesoderm development; metanephros development; negative regulation of cell proliferation; negative regulation of neuron differentiation; nervous system development; palate development; pancreas development; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development; spinal cord anterior/posterior patterning; ureteric bud development

NCBI Summary:The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]
UniProt Code:O95390
NCBI GenInfo Identifier:12643335
NCBI Gene ID:10220
NCBI Accession:O95390.1
UniProt Secondary Accession:O95390,Q9UID1, Q9UID2,
UniProt Related Accession:O95390
Molecular Weight:45,091 Da
NCBI Full Name:Growth/differentiation factor 11
NCBI Synonym Full Names:growth differentiation factor 11
NCBI Official Symbol:GDF11��
NCBI Official Synonym Symbols:BMP11; BMP-11��
NCBI Protein Information:growth/differentiation factor 11
UniProt Protein Name:Growth/differentiation factor 11
UniProt Synonym Protein Names:Bone morphogenetic protein 11; BMP-11
UniProt Gene Name:GDF11��
UniProt Entry Name:GDF11_HUMAN

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