Human GCP-2 Recombinant Protein (RPPB1140)
- SKU:
- RPPB1140
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P80162
- Research Area:
- Chemokines
Description
| Product Name: | Human GCP-2 Recombinant Protein |
| Product Code: | RPPB1140 |
| Size: | 20µg |
| Species: | Human |
| Target: | GCP-2 |
| Synonyms: | C-X-C motif chemokine 6, Chemokine alpha 3, CKA-3, Granulocyte chemotactic protein 2, GCP-2, Small-inducible cytokine B6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | GCP-2 protein was lyophilized from a 0.2 �m filtered concentrated solution in PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized GCP-2 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized GCP-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GCP-2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | VLTELRCTCL RVTLRVNPKT IGKLQVFPAG PQCSKVEVVA SLKNGKQVCL DPEAPFLKKV IQKILDSGNK KN |
| Biological Activity: | Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 10-50 ng/ml corresponding to a specific activity of 20,000-100,000 IU/mg. |
Granulocyte Chemotactic Protein 2 (CXCL6), also known as GCP-2, is a Chemotactic for neutrophil granulocytes. GCP-2 signals through binding and activation of its receptors (CXCR1 and CXCR2). GCP-2 has strong antibacterial activity against Gram-positive and Gram-negative bacteria In addition to its chemotactic and angiogenic property.
GCP-2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 72 amino acids and having a molecular mass of 7.9kDa.
| UniProt Protein Function: | CXCL6: Chemotactic for neutrophil granulocytes. Belongs to the intercrine alpha (chemokine CxC) family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: extracellular space; extracellular region Molecular Function:heparin binding; chemokine activity; CXCR chemokine receptor binding Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; defense response to bacterium; neutrophil mediated immunity; immune response; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; chemotaxis; signal transduction; inflammatory response; regulation of cell proliferation |
| UniProt Code: | P80162 |
| NCBI GenInfo Identifier: | 2851486 |
| NCBI Gene ID: | 6372 |
| NCBI Accession: | P80162.4 |
| UniProt Secondary Accession: | P80162,Q4W5D4, B2R4X3, |
| UniProt Related Accession: | P80162 |
| Molecular Weight: | 11,897 Da |
| NCBI Full Name: | C-X-C motif chemokine 6 |
| NCBI Synonym Full Names: | chemokine (C-X-C motif) ligand 6 |
| NCBI Official Symbol: | CXCL6�� |
| NCBI Official Synonym Symbols: | GCP2; CKA-3; GCP-2; SCYB6�� |
| NCBI Protein Information: | C-X-C motif chemokine 6; chemokine alpha 3; small-inducible cytokine B6; granulocyte chemotactic protein 2; Small inducible cytokine subfamily B (Cys-X-Cys), member b; chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2); small inducible cytokine subfamily B (Cys-X-Cys), member 6 (granulocyte chemotactic protein 2) |
| UniProt Protein Name: | C-X-C motif chemokine 6 |
| UniProt Synonym Protein Names: | Chemokine alpha 3; CKA-3; Granulocyte chemotactic protein 2; GCP-2; Small-inducible cytokine B6Cleaved into the following 3 chains:Small-inducible cytokine B6, N-processed variant 1; Small-inducible cytokine B6, N-processed variant 2; Small-inducible cytokine B6, N-processed variant 3 |
| UniProt Gene Name: | CXCL6�� |
| UniProt Entry Name: | CXCL6_HUMAN |
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