Human GAL Recombinant Protein (RPPB3578)
- SKU:
- RPPB3578
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P22466
Description
| Product Name: | Human GAL Recombinant Protein |
| Product Code: | RPPB3578 |
| Size: | 10µg |
| Species: | Human |
| Target: | GAL |
| Synonyms: | GALN, GLNN, GMAP, GAL, GAL1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The GAL solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSASAGLWS PAKEKRGWTL NSAGYLLGPH AVGNHRSFSD KNGLTSKREL RPEDDMKPGS FDRSIPENNI MRTIIEFLSF LHLKEAGALD RLLDLPAAASSEDIERS |
Galanin Prepropeptide (GAL) which is localized in brain pathways is involved in both cognition and affect, and also inhibits learning and memory by inhibiting neurotransmitter release and neuronal firing rate. GAL is a part of the galanin family and modulates a variety of physiological processed including cognition/memory, sensory/pain processing, neurotransmitter/hormone secretion, and feeding behavior. Galanin Prepropeptide is upregulated in primary afferent and sympathetic neurones and is required for the development of sympathetic perineuronal baskets subsequent to nerve injury.
GAL Human Recombinant produced in E. coli is a single polypeptide chain containing 127 amino acids (20-123) and having a molecular mass of 13.9kDa. GAL is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Galanin: Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion. Belongs to the galanin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q13.3 Cellular Component: Golgi apparatus; extracellular space; cell soma; extracellular region; secretory granule Molecular Function:type 3 galanin receptor binding; neuropeptide hormone activity; protein binding; type 2 galanin receptor binding; type 1 galanin receptor binding Biological Process: response to drug; nervous system development; positive regulation of cortisol secretion; positive regulation of apoptosis; positive regulation of catagen; negative regulation of lymphocyte proliferation; response to insulin stimulus; cAMP-mediated signaling; response to estrogen stimulus; neuropeptide signaling pathway; insulin secretion; regulation of glucocorticoid metabolic process; feeding behavior; positive regulation of transcription from RNA polymerase II promoter; inflammatory response Disease: Epilepsy, Familial Temporal Lobe, 8 |
| NCBI Summary: | Galanin is small neuropeptide that functions as a cellular messenger within the central and peripheral nervous systems, modulating diverse physiologic functions (Mechenthaler, 2008 [PubMed 18500643]).[supplied by OMIM, Jan 2009] |
| UniProt Code: | P22466 |
| NCBI GenInfo Identifier: | 2506449 |
| NCBI Gene ID: | 51083 |
| NCBI Accession: | P22466.3 |
| UniProt Secondary Accession: | P22466,Q14413, |
| UniProt Related Accession: | P22466 |
| Molecular Weight: | 13,302 Da |
| NCBI Full Name: | Galanin peptides |
| NCBI Synonym Full Names: | galanin/GMAP prepropeptide |
| NCBI Official Symbol: | GAL�� |
| NCBI Official Synonym Symbols: | GALN; GLNN; GMAP; GAL-GMAP�� |
| NCBI Protein Information: | galanin peptides; galanin prepropeptide; galanin-message-associated peptide; galanin-related peptide |
| UniProt Protein Name: | Galanin peptides |
| Protein Family: | Galanin |
| UniProt Gene Name: | GAL�� |
| UniProt Entry Name: | GALA_HUMAN |
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