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Human G3BP2 Recombinant Protein (RPPB1660)

SKU:
RPPB1660
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UN86
Research Area:
Enzymes
€309
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Description

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Product Name:Human G3BP2 Recombinant Protein
Product Code:RPPB1660
Size:20µg
Species:Human
Target:G3BP2
Synonyms:Ras GTPase-activating protein-binding protein 2, G3BP-2, GAP SH3 domain-binding protein 2, G3BP2, KIAA0660.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The G3BP2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 30% glycerol, 0.2M NaCl, 2mM DTT and 0.1mM PMSF.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMVMEKP SPLLVGREFV RQYYTLLNKA PEYLHRFYGR NSSYVHGGVD ASGKPQEAVY GQNDIHHKVL SLNFSECHTK IRHVDAHATL SDGVVVQVMG LLSNSGQPER KFMQTFVLAP EGSVPNKFYV HNDMFRYEDE VFGDSEPELD EESEDEVEEE QEERQPSPEP VQENANSGYY EAHPVTNGIE EPLEESSHEP EPEPESETKT EELKPQVEEK NLEELEEKST TPPPAEPVSL PQEPPKPRVE AKPEVQSQPP RVREQRPRER PGFPPRGPRP GRGDMEQNDS DNRRIIRYPD SHQLFVGNLP HDIDENELKE FFMSFGNVVE LRINTKGVGG KLPNFGFVVF DDSEPVQRIL IAKPIMFRGE VRLNVEEKKT RAARERETRG GGDDRRDIRR NDRGPGGPRG IVGGGMMRDR DGRGPPPRGG MAQKLGSGRG TGQMEGRFTG QRR

Ras GTPase-activating protein-binding protein 2 (G3BP2) is restricted to the plasma membrane and endocytic compartments and controls a fast endocytic recycling pathway. G3BP2 may be a scaffold protein which might be involved in mRNA transport.

G3BP2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 473 amino acids (1-449) and having a molecular mass of 53.3kDa.G3BP2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:G3BP-2: an hnRNA-binding protein and an element of the Ras signal transduction pathway. A DNA-unwinding enzyme which can unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. Binds specifically to the Ras-GTPase-activating protein (GAP120) by associating with its SH3 domain. Interacts with USP10, and may regulate it. Several alternatively spliced transcript variants have been described.
UniProt Protein Details:

Protein type:RNA-binding; Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: cytoplasm

Molecular Function:receptor signaling complex scaffold activity; nucleotide binding

Biological Process: cytoplasmic sequestering of NF-kappaB; mRNA transport; Ras protein signal transduction

UniProt Code:Q9UN86
NCBI GenInfo Identifier:116242482
NCBI Gene ID:9908
NCBI Accession:Q9UN86.2
UniProt Secondary Accession:Q9UN86,O60606, O75149, Q9UPA1, A8K6X1,
UniProt Related Accession:Q9UN86
Molecular Weight:482
NCBI Full Name:Ras GTPase-activating protein-binding protein 2
NCBI Synonym Full Names:GTPase activating protein (SH3 domain) binding protein 2
NCBI Official Symbol:G3BP2��
NCBI Protein Information:ras GTPase-activating protein-binding protein 2; G3BP-2; GAP SH3 domain-binding protein 2; Ras-GTPase activating protein SH3 domain-binding protein 2
UniProt Protein Name:Ras GTPase-activating protein-binding protein 2
UniProt Synonym Protein Names:GAP SH3 domain-binding protein 2
Protein Family:Ras GTPase-activating protein-binding protein
UniProt Gene Name:G3BP2��
UniProt Entry Name:G3BP2_HUMAN

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