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Human G CSF Recombinant Protein (RPPB0317)

SKU:
RPPB0317
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P09919
Research Area:
Growth Factors & Cytokines
€309
Frequently bought together:

Description

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Product Name:Human G CSF Recombinant Protein
Product Code:RPPB0317
Size:10µg
Species:Human
Target:G CSF
Synonyms:CSF-3, MGI-1G, GM-CSF beta, Pluripoietin, Filgrastim, Lenograstim, G-CSF, MGC45931, GCSF.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:Granulocyte Colony Stimulating Factor His is supplied in 1x PBS and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.

Granulocyte Colony Stimulating Factor is a growth factor and/or cytokine produced by the endothelium, macrophages and a number of other immune cells. GCSF stimulates the bone marrow to produce granulocytes and also to stimulate the survival, proliferation, differentiation and function of neutrophil granulocyte progenator cells and mature neutrophils.

Granulocyte Colony Stimulating Factor-His Tag Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 174 amino acids, fragment (31-204) and having a molecular mass of 23.19 kDa with an amino-terminal hexahistidine tag.G-CSF-His is purified by proprietary chromatographic techniques.

UniProt Protein Function:G-CSF: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytokine; Secreted, signal peptide; Cell cycle regulation; Secreted

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: extracellular space

Molecular Function:enzyme binding; growth factor activity; cytokine activity; granulocyte colony-stimulating factor receptor binding

Biological Process: positive regulation of protein binding; positive regulation of myeloid cell differentiation; granulocyte differentiation; multicellular organismal development; cytokine and chemokine mediated signaling pathway; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell proliferation; positive regulation of transcription factor import into nucleus; immune response; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
UniProt Code:P09919
NCBI GenInfo Identifier:117564
NCBI Gene ID:1440
NCBI Accession:P09919.1
UniProt Secondary Accession:P09919,A8MXR7,
UniProt Related Accession:P09919
Molecular Weight:18,434 Da
NCBI Full Name:Granulocyte colony-stimulating factor
NCBI Synonym Full Names:colony stimulating factor 3 (granulocyte)
NCBI Official Symbol:CSF3��
NCBI Official Synonym Symbols:GCSF; CSF3OS; C17orf33��
NCBI Protein Information:granulocyte colony-stimulating factor; filgrastim; lenograstim; pluripoietin
UniProt Protein Name:Granulocyte colony-stimulating factor
UniProt Synonym Protein Names:Pluripoietin; INN: Filgrastim; INN: Lenograstim
Protein Family:Granulocyte colony-stimulating factor
UniProt Gene Name:CSF3��
UniProt Entry Name:CSF3_HUMAN

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