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Nanodisc Human FZD8 Protein (HDFP238)

SKU:
HDFP238
Size:
10μg
Target:
FZD8
Tag:
C-Flag Tag
Expression Host:
HEK293
Conjugate:
Unconjugated
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Description

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Product Name:Nanodisc Human FZD8 Protein
SKU:HDFP238
Size:10μg
Target:FZD8
Tag:C-Flag Tag
Expression Host:HEK293
Conjugate:Unconjugated
Synonyms:FZ-8, hFZ8
Protein Families:Transmembrane, Druggable Genome.
Protein Description:Human FZD8 full length protein-synthetic nanodisc
Protein Pathways:Wnt NetPath 8, Wnt signaling, Wnt signaling and pluripotency, Cancer, Notch, Wnt Pathway, Stem Cell.
Molecular Weight:The human full length FZD8 protein has a MW of 73.3kDa

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]

Uniprot ID:Q9H461
Formulation & Reconstitution:Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping:Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Usage:Research use only

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