Nanodisc Human FZD8 Protein (HDFP238)
- SKU:
- HDFP238
- Size:
- 10μg
- Target:
- FZD8
- Tag:
- C-Flag Tag
- Expression Host:
- HEK293
- Conjugate:
- Unconjugated
Frequently bought together:
Description
Product Name: | Nanodisc Human FZD8 Protein |
SKU: | HDFP238 |
Size: | 10μg |
Target: | FZD8 |
Tag: | C-Flag Tag |
Expression Host: | HEK293 |
Conjugate: | Unconjugated |
Synonyms: | FZ-8, hFZ8 |
Protein Families: | Transmembrane, Druggable Genome. |
Protein Description: | Human FZD8 full length protein-synthetic nanodisc |
Protein Pathways: | Wnt NetPath 8, Wnt signaling, Wnt signaling and pluripotency, Cancer, Notch, Wnt Pathway, Stem Cell. |
Molecular Weight: | The human full length FZD8 protein has a MW of 73.3kDa |
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]
Uniprot ID: | Q9H461 |
Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Usage: | Research use only |