Human FRZB Recombinant Protein (RPPB3557)
- SKU:
- RPPB3557
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q92765
Description
| Product Name: | Human FRZB Recombinant Protein |
| Product Code: | RPPB3557 |
| Size: | 5µg |
| Species: | Human |
| Target: | FRZB |
| Synonyms: | Secreted frizzled-related protein 3, sFRP-3, Frezzled, Fritz, Frizzled-related protein 1, FrzB-1, FRZB, FIZ, FRE, FRP, FRZB1, SFRP3, OS1, FZRB, hFIZ, FRP-3, SFRP3, SRFP3, FRZB-PEN. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The FRZB solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.� |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPAACEPVR IPLCKSLPWN MTKMPNHLHH STQANAILAI EQFEGLLGTH CSPDLLFFLC AMYAPICTID FQHEPIKPCK SVCERARQGC EPILIKYRHS WPENLACEEL PVYDRGVCIS PEAIVTADGA DFPMDSSNGN CRGASSERCK CKPIRATQKT YFRNNYNYVI RAKVKEIKTK CHDVTAVVEV KEILKSSLVN IPRDTVNLYT SSGCLCPPLN VNEEYIIMGY EDEERSRLLL VEGSIAEKWK DRLGKKVKRW DMKLRHLGLS KSDSSNSDST QSQKSGRNSN PRQARNHHHH HH |
Frizzled-Related Protein (FRZB) is a secreted protein which is involved in the regulation of bone development. FRZB gene defects cause the female-specific osteoarthritis (OA) susceptibility. sFRPS (Soluble frizzled-related proteins) serve as modulators of Wnt signaling by direct interaction with Wnts. sFRPS have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB is involved in limb skeletogenesis. FRZB regulates chondrocyte maturation and long bone development.
FRZB produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 302 amino acids (33-325 a.a.) and having a molecular mass of 34.2kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).FRZB is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FRZB: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. Defects in FRZB are associated with susceptibility to osteoarthritis type 1(OS1). Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. Belongs to the secreted frizzled-related protein (sFRP) family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2q32.1 Cellular Component: extracellular space; membrane; integral to membrane Molecular Function:G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity Biological Process: negative regulation of cell proliferation; convergent extension involved in organogenesis; negative regulation of Wnt receptor signaling pathway; positive regulation of apoptosis; positive regulation of fat cell differentiation; neural crest cell differentiation; negative regulation of cell growth; skeletal development Disease: Osteoarthritis Susceptibility 1 |
| NCBI Summary: | The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010] |
| UniProt Code: | Q92765 |
| NCBI GenInfo Identifier: | 14194748 |
| NCBI Gene ID: | 2487 |
| NCBI Accession: | Q92765.2 |
| UniProt Secondary Accession: | Q92765,O00181, Q99686, |
| UniProt Related Accession: | Q92765 |
| Molecular Weight: | Calculated: 36kDaObserved: 38kDa |
| NCBI Full Name: | Secreted frizzled-related protein 3 |
| NCBI Synonym Full Names: | frizzled-related protein |
| NCBI Official Symbol: | FRZB�� |
| NCBI Official Synonym Symbols: | FRE; OS1; FZRB; hFIZ; FRITZ; FRP-3; FRZB1; SFRP3; SRFP3; FRZB-1; FRZB-PEN�� |
| NCBI Protein Information: | secreted frizzled-related protein 3; sFRP-3; frezzled; frizzled homolog-related; frizzled-related protein 1 |
| UniProt Protein Name: | Secreted frizzled-related protein 3 |
| UniProt Synonym Protein Names: | Frezzled; Fritz; Frizzled-related protein 1; FrzB-1 |
| Protein Family: | Frizzy aggregation protein |
| UniProt Gene Name: | FRZB�� |
| UniProt Entry Name: | SFRP3_HUMAN |
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