Human FOLR1 Recombinant Protein (RPPB3551)
- SKU:
- RPPB3551
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P15328
Description
| Product Name: | Human FOLR1 Recombinant Protein |
| Product Code: | RPPB3551 |
| Size: | 20µg |
| Species: | Human |
| Target: | FOLR1 |
| Synonyms: | Folate Receptor 1 (Adult), Ovarian Tumor-Associated Antigen MOv18, Adult Folate-Binding Protein, Folate Receptor Adult , KB Cells FBP, FR-Alpha, FOLR, FBP, Folate Binding Protein, Folate Receptor Alpha, Folate Receptor 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | FOLR1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSRIAWART ELLNVCMNAK HHKEKPGPED KLHEQCRPWR KNACCSTNTS QEAHKDVSYL YRFNWNHCGE MAPACKRHFI QDTCLYECSP NLGPWIQQVD QSWRKERVLN VPLCKEDCEQ WWEDCRTSYT CKSNWHKGWN WTSGFNKCAV GAACQPFHFY FPTPTVLCNE IWTHSYKVSN YSRGSGRCIQ MWFDPAQGNP NEEVARFYAA AMS |
FolateReceptor 1, also known as FOLR1, is a part of the folate receptor family whosemembers bind folic acid. FOLR1 binds to folate and reducedfolic acid derivatives and facilitates transfer of 5-methyltetrahydrofolate andfolate analogs into the cells. FOLR1is either attaches to membranes through a glycosyl-phosphatidylinositol linkageor exists in a soluble form. FOLR1 is also needed for embryonicdevelopment and normal cell proliferation.
FOLR1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 233 amino acids (25-234 a.a) and having a molecular mass of 27kDa. FOLR1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FOLR1: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain- specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function. Belongs to the folate receptor family. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 11q13.3-q14.1 Cellular Component: anchored to external side of plasma membrane; apical plasma membrane; basolateral plasma membrane; cell surface; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; Golgi membrane; integral to plasma membrane; membrane; nucleus Molecular Function:drug binding; folic acid binding; folic acid transporter activity; methotrexate binding; receptor activity Biological Process: axon regeneration; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; folic acid transport; heart looping; receptor-mediated endocytosis; regulation of transforming growth factor beta receptor signaling pathway Disease: Neurodegeneration Due To Cerebral Folate Transport Deficiency |
| NCBI Summary: | The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P15328 |
| NCBI GenInfo Identifier: | 544337 |
| NCBI Gene ID: | 2348 |
| NCBI Accession: | P15328.3 |
| UniProt Secondary Accession: | P15328,Q53EW2, Q6FGT8, Q6LC90, Q9UCT2, |
| UniProt Related Accession: | P15328 |
| Molecular Weight: | 29,819 Da |
| NCBI Full Name: | Folate receptor alpha |
| NCBI Synonym Full Names: | folate receptor 1 |
| NCBI Official Symbol: | FOLR1�� |
| NCBI Official Synonym Symbols: | FBP; FOLR�� |
| NCBI Protein Information: | folate receptor alpha |
| UniProt Protein Name: | Folate receptor alpha |
| UniProt Synonym Protein Names: | Adult folate-binding protein; FBP; Folate receptor 1; Folate receptor, adult; KB cells FBP; Ovarian tumor-associated antigen MOv18 |
| Protein Family: | Folate receptor |
| UniProt Gene Name: | FOLR1�� |
| UniProt Entry Name: | FOLR1_HUMAN |
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