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Human FLT-3/FLK-2 Recombinant Protein (Fc Tag)

SKU:
RPES6169
Product Type:
Recombinant Protein
Species:
Human
€359
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Description

Product Name:Human FLT-3/FLK-2 Recombinant Protein (Fc Tag)
Product Code:RPES6169
Size:10µg
Species:Human
Expression Host:HEK293 Cells
Synonyms:Receptor-Type Tyrosine-Protein Kinase FLT3, FL Cytokine Receptor, Fetal Liver Kinase-2, FLK-2, Fms-Like Tyrosine Kinase 3, FLT-3, Stem Cell Tyrosine Kinase 1, STK-1, CD135, FLT3, FLK2, STK1
Mol Mass:85.3 kDa
AP Mol Mass:120 kDa
Tag:C-Fc
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:< 1.0 EU per μg of the protein as determined by the LAL method.
Bio Activity:Testing in progress
Sequence:Asn27-Asn541(Thr227Met)
Accession:P36888
Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation:Supplied as a 0.2 μm filtered solution of PBS,PH7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:Not Applicable
Background:The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2and Stk-1is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the receptor for SCF and FMS, the receptor for M-CSF. The extracellular region of these receptors contains five immunoglobulin-like domains and the intracellular region contains a split kinase domain. Human Flt-3 cDNA encodes a 993 amino acid (aa) residue type I membrane protein with a 26 aa residue signal peptide, a 515 aa extracellular domain with 10 potential N-linked glycosylation sites, a 21 aa residue transmembrane domain and a 431 aa residue cytoplasmic domain. Flt-3 expression has been detected in various tissues, including placenta, gonads, and tissues of nervous and hematopoietic origin. Among hematopoietic cells, the expression of Flt-3 was found to be restricted to the highly enriched stem/progenitor cell populations. The ligand for Flt-3 (FL) has been identified to be a transmembrane protein with structural homology to M-CSF and SCF. Recombinant soluble Flt-3/Fc chimeric protein has been shown to bind FL with high affinity and is a potent FL antagonist.

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