Human FKBP6 Recombinant Protein (RPPB1646)
- SKU:
- RPPB1646
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O75344
- Research Area:
- Enzymes
Description
| Product Name: | Human FKBP6 Recombinant Protein |
| Product Code: | RPPB1646 |
| Size: | 10µg |
| Species: | Human |
| Target: | FKBP6 |
| Synonyms: | FKBP36, EC 5.2.1.8, FKBP-6, PPIase, MGC87179, FK506-binding protein 6, Rotamase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | FKBP6 Human solution containing 20mM Tris-HCl pH-8, 1mM DTT, 1mM EDTA, 50mM NaCl & 40% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGGSALNQGV LEGDDAPGQS LYERLSQRML DISGDRGVLK DVIREGAGDL VAPDASVLVK YSGYLEHMDR PFDSNYFRKT PRLMKLGEDI TLWGMELGLL SMRRGELARF LFKPNYAYGT LGCPPLIPPN TTVLFEIELL DFLDCAESDK FCALSAEQQD QFPLQKVLKV AATEREFGNY LFRQNRFYDA KVRYKRALLL LRRRSAPPEE QHLVEAAKLP VLLNLSFTYL KLDRPTIALC YGEQALIIDQ KNAKALFRCG QACLLLTEYQ KARDFLVRAQ KEQPFNHDIN NELKKLASCY RDYVDKEKEM WHRMFAPCGD GSTAGES |
| Biological Activity: | Specific activity is > 190 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin. |
FKBP6 is part of the immunophilin protein family, and is involved in immunoregulation and basic cellular functions involving protein folding and trafficking. FKBP6 is widely expressed in all tissues, FKBP6 is present at utmost levels in testis, liver, kidney, skeletal muscle and heart. Deletion of FKBP6 contributes to hypercalcemia and growth delay in Williams-Beuren syndrome.
FKBP6 Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 347 amino acids (1-327 a.a.) and having a molecular mass of 39.3 kDa. FKBP6 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.
| UniProt Protein Function: | FKBP6: PPIases accelerate the folding of proteins. FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Isomerase; EC 5.2.1.8 Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: endoplasmic reticulum membrane; cytoplasm; synaptonemal complex; cytosol Molecular Function:protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; Hsp90 protein binding Biological Process: meiosis; protein peptidyl-prolyl isomerization; protein folding; DNA methylation during gametogenesis; spermatogenesis; RNA-mediated gene silencing; cell differentiation |
| NCBI Summary: | The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | O75344 |
| NCBI GenInfo Identifier: | 13124184 |
| NCBI Gene ID: | 8468 |
| NCBI Accession: | O75344.1 |
| UniProt Related Accession: | O75344 |
| Molecular Weight: | ~ 37kDa |
| NCBI Full Name: | Inactive peptidyl-prolyl cis-trans isomerase FKBP6 |
| NCBI Synonym Full Names: | FKBP prolyl isomerase 6 |
| NCBI Official Symbol: | FKBP6�� |
| NCBI Official Synonym Symbols: | FKBP36�� |
| NCBI Protein Information: | inactive peptidyl-prolyl cis-trans isomerase FKBP6 |
| UniProt Protein Name: | Inactive peptidyl-prolyl cis-trans isomerase FKBP6 |
| UniProt Synonym Protein Names: | 36 kDa FK506-binding protein; 36 kDa FKBP; FKBP-36; FK506-binding protein 6; FKBP-6; Immunophilin FKBP36 |
| Protein Family: | FK506-binding protein |
| UniProt Gene Name: | FKBP6�� |
| UniProt Entry Name: | FKBP6_HUMAN |
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