Human FKBP5 Recombinant Protein (RPPB1645)
- SKU:
- RPPB1645
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q13451
- Research Area:
- Enzymes
Description
| Product Name: | Human FKBP5 Recombinant Protein |
| Product Code: | RPPB1645 |
| Size: | 10µg |
| Species: | Human |
| Target: | FKBP5 |
| Synonyms: | FK506 Binding Protein 5, 54 KDa Progesterone Receptor-Associated Immunophilin, 51 KDa FK506-Binding Protein, Androgen-Regulated Protein 6, HSP90-Binding Immunophilin, FK506-Binding Protein 5, PPIase FKBP5, 51 KDa FKBP, FF1 Antigen, EC 5.2.1.8, Rotamase, FKBP-51, FKBP51, FKBP54, AIG6, P54, Peptidylprolyl Cis-Trans Isomerase, T-Cell FK506-Binding Protein, PPIASE, Ptg-10, FKBP-5, FKBP5. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | FKBP5 was filtered (0.4�m) and lyophilized in 20mM Tris buffer and 50mM NaCl, pH 7.5. |
| Solubility: | It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Filter sterilize your culture media/working solutions containing this non-sterile FKBP5 before using in cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHAS�MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV |
FK506 Binding Protein 5 (FKBP5) belongs to the immunophilin protein family, which has a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP5 is a cis-trans prolyl isomerase, which binds to the immunosuppressants FK506 and rapamycin. FKBP5 is an immunophilin protein with PPIase and co-chaperone activities. FKBP5 is assumed to mediate calcineurin inhibition. FKBP5 is a component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). In addition, FKBP5 interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein.
FKBP5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Met1-Val457) containing 467 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 52.5kDa.
| UniProt Protein Function: | FKBP5: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid. By androgen. Widely expressed, enriched in testis compared to other tissues. Inhibited by FK506 but not cyclosporin. |
| UniProt Protein Details: | Protein type:EC 5.2.1.8; Isomerase; Chaperone Chromosomal Location of Human Ortholog: 6p21.31 Cellular Component: nucleoplasm; endoplasmic reticulum membrane; membrane Molecular Function:protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; heat shock protein binding Biological Process: protein peptidyl-prolyl isomerization; protein folding Disease: Major Depressive Disorder |
| NCBI Summary: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] |
| UniProt Code: | Q13451 |
| NCBI GenInfo Identifier: | 2851536 |
| NCBI Gene ID: | 2289 |
| NCBI Accession: | Q13451.2 |
| UniProt Related Accession: | Q13451 |
| Molecular Weight: | 51kDa |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase FKBP5 |
| NCBI Synonym Full Names: | FKBP prolyl isomerase 5 |
| NCBI Official Symbol: | FKBP5�� |
| NCBI Official Synonym Symbols: | P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10�� |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase FKBP5 |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase FKBP5 |
| UniProt Synonym Protein Names: | 51 kDa FK506-binding protein; 51 kDa FKBP; FKBP-51; 54 kDa progesterone receptor-associated immunophilin; Androgen-regulated protein 6; FF1 antigen; FK506-binding protein 5; FKBP-5; FKBP54; p54; HSP90-binding immunophilin; Rotamase |
| Protein Family: | FK506-binding protein |
| UniProt Gene Name: | FKBP5�� |
| UniProt Entry Name: | FKBP5_HUMAN |
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