Human FHL3 Recombinant Protein (RPPB3542)
- SKU:
- RPPB3542
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q13643
Description
| Product Name: | Human FHL3 Recombinant Protein |
| Product Code: | RPPB3542 |
| Size: | 10µg |
| Species: | Human |
| Target: | FHL3 |
| Synonyms: | Four And A Half LIM Domains 3, SLIM2, Skeletal MuscleLIM-Protein 2, FHL-3, SLIM-2, Four And A Half LIM Domains Protein 3, LIM-OnlyProtein FHL3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | FHL3 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSESFDC AKCNESLYGR KYIQTDSGPY CVPCYDNTFA NTCAECQQLI GHDSRELFYE DRHFHEGCFR CCRCQRSLAD EPFTCQDSEL LCNDCYCSAF SSQCSACGET VMPGSRKLEY GGQTWHEHCF LCSGCEQPLG SRSFVPDKGA HYCVPCYENK FAPRCARCSK TLTQGGVTYR DQPWHRECLV CTGCQTPLAG QQFTSRDEDP YCVACFGELF APKCSSCKRP IVGLGGGKYV SFEDRHWHHN CFSCARCSTS LVGQGFVPDG DQVLCQGCSQ AGP |
Fourand a half LIM domains 3 (FHL3) belongs to a family of proteins containing afour-and-a-half LIM domain, which is a highly conserved double zinc fingermotif. FHL3 has been shown to interact with the cancer developmental regulatorsSMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and thehigh-affinity IgE beta chain regulator MZF-1. FHL3 is involved in tumorsuppression, repression of MyoD expression, and repression of IgE receptorexpression. Two transcript variants encoding different isoforms have been foundfor this gene.
FHL3 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 303 amino acids (1-280 a.a) andhaving a molecular mass of 33.6kDa.�FHL3 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| NCBI Summary: | The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q13643 |
| NCBI GenInfo Identifier: | 54112385 |
| NCBI Gene ID: | 2275 |
| NCBI Accession: | NP_004459.2 |
| UniProt Secondary Accession: | Q13643,Q6I9T0, Q9BVA2, D3DPT6, |
| UniProt Related Accession: | Q13643 |
| Molecular Weight: | 31,192 Da |
| NCBI Full Name: | four and a half LIM domains protein 3 isoform 1 |
| NCBI Synonym Full Names: | four and a half LIM domains 3 |
| NCBI Official Symbol: | FHL3�� |
| NCBI Official Synonym Symbols: | SLIM2�� |
| NCBI Protein Information: | four and a half LIM domains protein 3 |
| UniProt Protein Name: | |
| Protein Family: | Four and a half LIM domains protein |
| UniProt Gene Name: |
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