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Human FHL2 Recombinant Protein (RPPB3541)

SKU:
RPPB3541
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q14192
€309
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Description

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Product Name:Human FHL2 Recombinant Protein
Product Code:RPPB3541
Size:25µg
Species:Human
Target:FHL2
Synonyms:AAG11, DRAL, FHL-2, SLIM-3, SLIM3, Four and a half LIMdomains protein 2, LIM domain protein DRAL, Skeletal muscle LIM-protein 3, FHL2, RNA Binding Motif Protein 18, RNA-Binding Motif Protein 18, RBM18.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:FHL2 protein solution (0.5mg/ml) containing 20mM Tris-HClbuffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMTERFDC HHCNESLFGK KYILREESPY CVVCFETLFA NTCEECGKPIGCDCKDLSYK DRHWHEACFH CSQCRNSLVD KPFAAKEDQL LCTDCYSNEY SSKCQECKKT IMPGTRKMEYKGSSWHETCF ICHRCQQPIG TKSFIPKDNQ NFCVPCYEKQ HAMQCVQCKK PITTGGVTYR EQPWHKECFV CTACRKQLSG QRFTARDDFAYCLNCFCDLY AKKCAGCTNP ISGLGGTKYI SFEERQWHND CFNCKKCSLS LVGRGFLTER DDILCPDCGK DI

Four And A Half LIM Domains 2 (FHL2)belongs to the four-and-a-half-LIM-only protein family. Family members arecomprised of 2 highly conserved, tandemly arranged, zinc finger domains with 4highly conserved cysteines binding a zinc atom in each zinc finger. The FHL2protein is assumed to play a part in the assembly of extracellular membranes.Furthermore, FHL2 is down-regulated during transformation of normal myoblaststo rhabdomyosarcoma cells and the FHL2 functions as a link between presenilin-2and an intracellular signaling pathway.

FHL2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 302 amino acids (1-279 a.a) and having a molecular mass of 34.6kDa. FHL2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:FHL2: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 2q12.2

Cellular Component: nucleoplasm; focal adhesion; M band; nucleus; Z disc; actin cytoskeleton

Molecular Function:identical protein binding; protein binding; androgen receptor binding; zinc ion binding; transcription coactivator activity; transcription factor binding

Biological Process: osteoblast differentiation; atrial cardiac muscle cell development; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; ventricular cardiac muscle cell development; androgen receptor signaling pathway; response to hormone stimulus; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of apoptosis

NCBI Summary:This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]
UniProt Code:Q14192
NCBI GenInfo Identifier:116241364
NCBI Gene ID:2274
NCBI Accession:Q14192.3
UniProt Related Accession:Q14192
Molecular Weight:~ 32kDa
NCBI Full Name:Four and a half LIM domains protein 2
NCBI Synonym Full Names:four and a half LIM domains 2
NCBI Official Symbol:FHL2��
NCBI Official Synonym Symbols:DRAL; AAG11; FHL-2; SLIM3; SLIM-3��
NCBI Protein Information:four and a half LIM domains protein 2
UniProt Protein Name:Four and a half LIM domains protein 2
UniProt Synonym Protein Names:LIM domain protein DRAL; Skeletal muscle LIM-protein 3; SLIM-3
Protein Family:Four and a half LIM domains protein
UniProt Gene Name:FHL2��
UniProt Entry Name:FHL2_HUMAN

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