Human FGF20 Recombinant Protein (RPPB0240)
- SKU:
- RPPB0240
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NP95
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human FGF20 Recombinant Protein |
| Product Code: | RPPB0240 |
| Size: | 15µg |
| Species: | Human |
| Target: | FGF20 |
| Synonyms: | Fibroblast Growth Factor 20, FGF-20, RHDA2, FGF20. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered solution in MOPS, (NH4)2SO4, DTT and EDTA. |
| Solubility: | It is recommended to reconstitute the lyophilized FGF-20 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized FGF20 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FGF-20 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MHHHHHHAPL AEVGGFLGGL EGLGQQVGSH FLLPPAGERP PLLGERRSAA ERSARGGPGA AQLAHLHGIL RRRQLYCRTG FHLQILPDGS VQGTRQDHSL FGILEFISVA VGLVSIRGVD SGLYLGMNDK GELYGSEKLT SECIFREQFE ENWYNTYSSN IYKHGDTGRR YFVALNKDGT PRDGARSKRH QKFTHFLPRP VDPERVPELY KDLLMYT |
| Biological Activity: | The ED50, as measured in a proliferation assay using mouse NR6R-3T3 cells, is less than 2.5ng/ml. |
Fibroblast growth factor 20 (FGF20) belongs to the FGF gene family and member of FGF-9 subfamily (based upon its structure). Human FGF20 has several receptors which include FGF R1c, FGF R2c, FGF R3b, FGF R3c and FGF R4. FGF20 is expressed a various cells, including dopaminergic neurons, fibroblasts, keratinocytes and breast epithelium, and numerous sites in the fetus.
FGF20 Human Recombinant (1-211) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 217 amino acids and having a molecular mass of 24kDa.The FGF-20 is fused to a 6 amino acid His tag [HHHHHH] at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FGF20: Neurotrophic factor that regulates central nervous development and function. Belongs to the heparin-binding growth factors family. |
| UniProt Protein Details: | Protein type:Cytokine Chromosomal Location of Human Ortholog: 8p22 Cellular Component: extracellular region Molecular Function:1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity Biological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade; signal transduction Disease: Renal Hypodysplasia/aplasia 2 |
| NCBI Summary: | The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9NP95 |
| NCBI GenInfo Identifier: | 13626702 |
| NCBI Gene ID: | 26281 |
| NCBI Accession: | Q9NP95.1 |
| UniProt Secondary Accession: | Q9NP95,B2RPH5, |
| UniProt Related Accession: | Q9NP95 |
| Molecular Weight: | 23,499 Da |
| NCBI Full Name: | Fibroblast growth factor 20 |
| NCBI Synonym Full Names: | fibroblast growth factor 20 |
| NCBI Official Symbol: | FGF20�� |
| NCBI Official Synonym Symbols: | RHDA2; FGF-20�� |
| NCBI Protein Information: | fibroblast growth factor 20 |
| UniProt Protein Name: | Fibroblast growth factor 20 |
| Protein Family: | Fibroblast growth factor |
| UniProt Gene Name: | FGF20�� |
| UniProt Entry Name: | FGF20_HUMAN |
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