Human FGF16 Recombinant Protein (RPPB0229)
- SKU:
- RPPB0229
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O43320
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human FGF16 Recombinant Protein |
| Product Code: | RPPB0229 |
| Size: | 25µg |
| Species: | Human |
| Target: | FGF16 |
| Synonyms: | Fibroblast Growth Factor 16, Metacarpal 4-5 Fusion, FGF-16, MF4, FGF16. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless clear solution. |
| Formulation: | FGF-16 0.2�m filtered solution containing 20mM Tris-HCl, 1M NaCl, pH 9.0, 0.2% Tween-20 and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | AEVGGVFASL DWDLHGFSSS LGNVPLADSP GFLNERLGQI EGKLQRGSPT DFAHLKGILR RRQLYCRTGF HLEIFPNGTV HGTRHDHSRF GILEFISLAV GLISIRGVDS GLYLGMNERG ELYGSKKLTR ECVFREQFEE NWYNTYASTL YKHSDSERQY YVALNKDGSP REGYRTKRHQ KFTHFLPRPV DPSKLPSMSR DLFHYR |
| Biological Activity: | The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5ng/ml, corresponding to a specific activity of > 2.0 � 106 IU/mg. |
Fibroblast growth factor 16 (FGF16) is a member of the large FGF family, whose members are heparin-binding growth factors with a core 120 amino acid (a.a.) FGF domain which allows for a common tertiary structure. Human FGF16 cDNA is a 207 aa precursor protein with one N-linked glycosylation site. FGF16 though lacking a typical signal peptide, is efficiently produced by mechanisms other than the classical protein secretion pathway. FGF16 is expressed in cardiac cells and is required for proper heart development. FGF16 gene mutation was also observed in individuals with metacarpal 4-5 fusion. FGF16 has an imperative role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.
FGF16 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 206 amino acids and having a molecular mass of 23.6kDa.The FGF-16 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FGF16: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Belongs to the heparin-binding growth factors family.Protein type: CytokineChromosomal Location of Human Ortholog: Xq13Cellular Component: extracellular region; extracellular spaceMolecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activityBiological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; metabolic process; organ morphogenesis; phosphoinositide-mediated signaling; regulation of endothelial cell proliferation; regulation of MAP kinase activity; regulation of phosphoinositide 3-kinase cascade; response to temperature stimulus; signal transductionDisease: Metacarpal 4-5 Fusion |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014] |
| UniProt Code: | O43320 |
| NCBI GenInfo Identifier: | 6015145 |
| NCBI Gene ID: | 8823 |
| NCBI Accession: | O43320.1 |
| UniProt Secondary Accession: | O43320 |
| UniProt Related Accession: | O43320 |
| Molecular Weight: | 23,759 Da |
| NCBI Full Name: | Fibroblast growth factor 16 |
| NCBI Synonym Full Names: | fibroblast growth factor 16 |
| NCBI Official Symbol: | FGF16�� |
| NCBI Official Synonym Symbols: | MF4; FGF-16�� |
| NCBI Protein Information: | fibroblast growth factor 16 |
| UniProt Protein Name: | Fibroblast growth factor 16 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Fibroblast growth factor |
| UniProt Gene Name: | FGF16�� |
| UniProt Entry Name: | FGF16_HUMAN |
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