Human FGF14 Recombinant Protein (RPPB0227)
- SKU:
- RPPB0227
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q92915
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human FGF14 Recombinant Protein |
| Product Code: | RPPB0227 |
| Size: | 10µg |
| Species: | Human |
| Target: | FGF14 |
| Synonyms: | Fibroblast growth factor 14, FGF-14, Fibroblast growth factor homologous factor 4, FHF-4, FGF14, FHF4, SCA27, bA397O8.2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | FGF14 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.2M NaCl, 50% glycerol and 5mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMAAAIA SGLIRQKRQA REQHWDRPSA SRRRSSPSKN RGLCNGNLVD IFSKVRIFGL KKRRLRRQDP QLKGIVTRLY CRQGYYLQMH PDGALDGTKD DSTNSTLFNL IPVGLRVVAI QGVKTGLYIA MNGEGYLYPS ELFTPECKFK ESVFENYYVI YSSMLYRQQE SGRAWFLGLN KEGQAMKGNR VKKTKPAAHF LPKPLEVAMY REPSLHDVGE TVPKPGVTPS KSTSASAIMN GGKPVNKSKT T |
Fibroblast Growth Factor 14 (FGF14) belongs to the fibroblast growth factor (FGF) family. FGF family members have broad mitogenic and cell survival activities, and are involved in a various biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF14 gene mutation is linked with autosomal dominant cerebral ataxia.
FGF14 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 271 amino acids (1-247 a.a) and having a molecular mass of 30kDa.FGF14 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FGF14: Probably involved in nervous system development and function. Defects in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine; Cell development/differentiation Chromosomal Location of Human Ortholog: 13q34 Cellular Component: extracellular region; nucleus Molecular Function:heparin binding; growth factor activity; fibroblast growth factor receptor binding Biological Process: nervous system development; synaptic transmission; fibroblast growth factor receptor signaling pathway; cell-cell signaling; adult locomotory behavior; neuromuscular process; JNK cascade; signal transduction Disease: Spinocerebellar Ataxia 27 |
| NCBI Summary: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92915 |
| NCBI GenInfo Identifier: | 2494463 |
| NCBI Gene ID: | 2259 |
| NCBI Accession: | Q92915.1 |
| UniProt Secondary Accession: | Q92915,Q86YN7, Q96QX6, |
| UniProt Related Accession: | Q92915 |
| Molecular Weight: | 247 |
| NCBI Full Name: | Fibroblast growth factor 14 |
| NCBI Synonym Full Names: | fibroblast growth factor 14 |
| NCBI Official Symbol: | FGF14�� |
| NCBI Official Synonym Symbols: | FHF4; FHF-4; SCA27; FGF-14�� |
| NCBI Protein Information: | fibroblast growth factor 14; bA397O8.2; fibroblast growth factor homologous factor 4 |
| UniProt Protein Name: | Fibroblast growth factor 14 |
| UniProt Synonym Protein Names: | Fibroblast growth factor homologous factor 4; FHF-4 |
| Protein Family: | Fibroblast growth factor |
| UniProt Gene Name: | FGF14�� |
| UniProt Entry Name: | FGF14_HUMAN |
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