Human FGF13 Recombinant Protein (RPPB0226)
- SKU:
- RPPB0226
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q92913
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human FGF13 Recombinant Protein |
| Product Code: | RPPB0226 |
| Size: | 25µg |
| Species: | Human |
| Target: | FGF13 |
| Synonyms: | Fibroblast growth factor 13, FGF-13, Fibroblast growth factor homologous factor 2, FHF-2, FGF13, FHF2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | FGF13 protein was lyophilized from a 0.2�m filtered concentrated solution in 20mM PB, 0.5M NaCl, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized FGF-13 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized FGF13 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FGF-13 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MAAAIASSLI RQKRQARERE KSNACKCVSS PSKGKTSCDK NKLNVFSRVK LFGSKKRRRR RPEPQLKGIV TKLYSRQGYH LQLQADGTID GTKDEDSTYT LFNLIPVGLR VVAIQGVQTK LYLAMNSEGY LYTSELFTPE CKFKESVFEN YYVTYSSMIY RQQQSGRGWY LGLNKEGEIM KGNHVKKNKP AAHFLPKPLK VAMYKEPSLH DLTEFSRSGS GTPTKSRSVS GVLNGGKSMS HNEST |
Fibroblast growth factor 13 (FGF-13) is a member of the large FGF family which has at least 23 members. Most of its members are binding growth factors with a core 120 amino acid (aa) FGF domain which allows for a mutual tertiary structure. Human and mouse FGF13 are 245 aa proteins which arise from genes that show N-terminal alternative splicing. Transcripts for 245 aa, 199 aa, 226 aa, 192 aa and 255 aa have been identified in human and mouse, with almost complete cross-species aa identity among all splice forms (greater than 98%). FGF13 is identified in the fetal ependyma, dorsal root and cranial ganglia, both atrial and ventricular myocardium, and in renal collecting duct-associated mesenchyme.
FGF13 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 245 amino acids and having a molecular mass of 27.6kDa.The FGF-13 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. |
| NCBI Summary: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008] |
| UniProt Code: | Q92913 |
| NCBI GenInfo Identifier: | 2494461 |
| NCBI Gene ID: | 2258 |
| NCBI Accession: | Q92913.1 |
| UniProt Secondary Accession: | Q92913,O95830, Q9NZH9, Q9NZI0, B1AK18, B7Z4M7, B7Z8N0 D3DWH4, |
| UniProt Related Accession: | Q92913 |
| Molecular Weight: | 25,607 Da |
| NCBI Full Name: | Fibroblast growth factor 13 |
| NCBI Synonym Full Names: | fibroblast growth factor 13 |
| NCBI Official Symbol: | FGF13�� |
| NCBI Official Synonym Symbols: | FGF2; FHF2; FHF-2; FGF-13�� |
| NCBI Protein Information: | fibroblast growth factor 13 |
| UniProt Protein Name: | Fibroblast growth factor 13 |
| UniProt Synonym Protein Names: | Fibroblast growth factor homologous factor 2; FHF-2 |
| Protein Family: | Fibroblast growth factor |
| UniProt Gene Name: | FGF13�� |
| UniProt Entry Name: | FGF13_HUMAN |
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