Human FCER1A Recombinant Protein (RPPB3522)
- SKU:
- RPPB3522
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P12319
Description
| Product Name: | Human FCER1A Recombinant Protein |
| Product Code: | RPPB3522 |
| Size: | 20µg |
| Species: | Human |
| Target: | FCER1A |
| Synonyms: | Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide,FCE1A, IgE Fc Receptor Subunit Alpha, FcERI, Fc-Epsilon RI-Alpha, Fc Epsilon RIAlpha-Chain, Fc IgE Receptor, Alpha Polypeptide, High Affinity ImmunoglobulinEpsilon Receptor Alpha-Subunit, High Affinity Immunoglobulin Epsilon ReceptorSubunit Alpha, Immunoglobulin E Receptor, High-Affinity, Of Mast Cells, AlphaPolypeptide. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | FCER1A protein solution (0.25mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSVPQKPKV SLNPPWNRIF KGENVTLTCN GNNFFEVSST KWFHNGSLSEETNSSLNIVN AKFEDSGEYK CQHQQVNESE PVYLEVFSDW LLLQASAEVV MEGQPLFLRC HGWRNWDVYKVIYYKDGEAL KYWYENHNIS ITNATVEDSG TYYCTGKVWQ LDYESEPLNI TVIKAPREKY WLQ |
Fcfragment of IgE, high affinity I, receptor for; alpha polypeptide (FCER1A)binds to the Fc region of immunoglobulins epsilon. FCER1A is a high affinityreceptor. In addition FCER1A is responsible for starting the allergic response.Binding of allergen to receptor-bound IgE leads to cell activation and therelease of mediators such as histamine which is responsible for themanifestations of allergy. This receptor is contains of an alpha subunit, abeta subunit, and two gamma subunits. FCER1A stands for the alpha subunit.Among the diseases associated with FCER1A are mast-cell leukemia, and allergicasthma.
FCER1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 203 amino acids (26-205aa) and having a molecular mass of 23.4kDa.FCER1A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. |
| NCBI Summary: | The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P12319 |
| NCBI GenInfo Identifier: | 119865 |
| NCBI Gene ID: | 2205 |
| NCBI Accession: | P12319.1 |
| UniProt Related Accession: | P12319 |
| Molecular Weight: | 30kDa |
| NCBI Full Name: | High affinity immunoglobulin epsilon receptor subunit alpha |
| NCBI Synonym Full Names: | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide |
| NCBI Official Symbol: | FCER1A�� |
| NCBI Official Synonym Symbols: | FCE1A; FcERI�� |
| NCBI Protein Information: | high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypeptide; high affinity immunoglobulin epsilon receptor alpha-subunit; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide |
| UniProt Protein Name: | High affinity immunoglobulin epsilon receptor subunit alpha |
| UniProt Synonym Protein Names: | Fc-epsilon RI-alpha; FcERI; IgE Fc receptor subunit alpha |
| Protein Family: | High affinity immunoglobulin epsilon receptor |
| UniProt Gene Name: | FCER1A�� |
| UniProt Entry Name: | FCERA_HUMAN |
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