Human FBXO2 Recombinant Protein (RPPB3520)
- SKU:
- RPPB3520
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UK22
Description
| Product Name: | Human FBXO2 Recombinant Protein |
| Product Code: | RPPB3520 |
| Size: | 10µg |
| Species: | Human |
| Target: | FBXO2 |
| Synonyms: | F-box only protein 2, FBXO2, F-Box Protein 2, FBX2, FBG1, Fbs1, NFB42, OCP1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | FBXO2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDGDGDP ESVGQPEEAS PEEQPEEASA EEERPEDQQE EEAAAAAAYL DELPEPLLLR VLAALPAAEL VQACRLVCLR WKELVDGAPL WLLKCQQEGL VPEGGVEEER DHWQQFYFLS KRRRNLLRNP CGEEDLEGWC DVEHGGDGWR VEELPGDSGV EFTHDESVKK YFASSFEWCR KAQVIDLQAE GYWEELLDTT QPAIVVKDWY SGRSDAGCLY ELTVKLLSEH ENVLAEFSSG QVAVPQDSDG GGWMEISHTF TDYGPGVRFV RFEHGGQDSV YWKGWFGARV TNSSVWVEP |
F-Box Protein 2 (FBXO2) is a part of the F-box protein family. The F-box proteins are one of the 4 subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which takes part in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes. FBXO2 belongs to the Fbxs class which contains either different protein-protein interaction modules or no recognizable motifs. FBXO2 is extremely similar to the rat neural F Box 42 kDa protein which is enriched in the nervous system and plays a role in maintaining neurons in a postmitotic state.
FBXO2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 319 amino acids (1-296 a.a.) and having a molecular mass of 35.7kDa.FBXO2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FBXO2: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: endoplasmic reticulum; dendritic spine; SCF ubiquitin ligase complex; cytosol Molecular Function:beta-amyloid binding; ubiquitin-protein ligase activity; carbohydrate binding; glycoprotein binding Biological Process: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of cell proliferation; ER-associated protein catabolic process; regulation of protein ubiquitination; protein ubiquitination; protein modification process; glycoprotein catabolic process; proteolysis |
| NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UK22 |
| NCBI GenInfo Identifier: | 15812198 |
| NCBI Gene ID: | 26232 |
| NCBI Accession: | NP_036300.2 |
| UniProt Secondary Accession: | Q9UK22,Q5TGY0, Q6FGJ7, Q8TB29, Q9UKC6, B2R7K7, |
| UniProt Related Accession: | Q9UK22 |
| Molecular Weight: | 60.3 kDa |
| NCBI Full Name: | F-box only protein 2 |
| NCBI Synonym Full Names: | F-box protein 2 |
| NCBI Official Symbol: | FBXO2�� |
| NCBI Official Synonym Symbols: | FBG1; FBX2; Fbs1; OCP1; NFB42�� |
| NCBI Protein Information: | F-box only protein 2; F-box gene 1; organ of Corti protein 1 |
| UniProt Protein Name: | F-box only protein 2 |
| Protein Family: | F-box only protein |
| UniProt Gene Name: | FBXO2�� |
| UniProt Entry Name: | FBX2_HUMAN |
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