Human FAM3C Recombinant Protein (RPPB3510)
- SKU:
- RPPB3510
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q92520
Description
| Product Name: | Human FAM3C Recombinant Protein |
| Product Code: | RPPB3510 |
| Size: | 10µg |
| Species: | Human |
| Target: | FAM3C |
| Synonyms: | Family with sequence similarity 3 member C, ILEI, Interleukin-like EMT inducer, predicted osteoblast protein, GS3876, protein FAM3C. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The FAM3C solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 5mM DTT, 200mM NaCl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MQVFEIKMDA SLGNLFARSA LDTAARSTKP PRYKCGISKA CPEKHFAFKM ASGAANVVGP KICLEDNVLM SGVKNNVGRG INVALANGKT GEVLDTKYFD MWGGDVAPFI EFLKAIQDGT IVLMGTYDDG ATKLNDEARR LIADLGSTSI TNLGFRDNWV FCGGKGIKTK SPFEQHIKNN KDTNKYEGWP EVVEMEGCIP QKQD |
FAM3C is a member of the FAM3 family and holds a GG domain. Pancreatic cancer-derived cells demonstrate a difference in expression of this protein. FAM3C is a downstream target gene for the Nkx5-1 transcription factor, and there for takes part in cell differentiation and proliferation through inner ear embryogenesis. In addition, FAM3C has a role in retinal laminar formation and promotes epithelial to mesenchymal transition.
FAM3C Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 224 amino acids (25-227) and having a molecular mass of 24.5 kDa.FAM3C is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FAM3C: May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. Belongs to the FAM3 family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 7q31 Cellular Component: Golgi apparatus; cytoplasmic membrane-bound vesicle; extracellular region Molecular Function:cytokine activity Biological Process: multicellular organismal development |
| NCBI Summary: | This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q92520 |
| NCBI GenInfo Identifier: | 3334194 |
| NCBI Gene ID: | 10447 |
| NCBI Accession: | Q92520.1 |
| UniProt Secondary Accession: | Q92520,A6NDN2, A8K3R7, |
| UniProt Related Accession: | Q92520 |
| Molecular Weight: | 227 |
| NCBI Full Name: | Protein FAM3C |
| NCBI Synonym Full Names: | family with sequence similarity 3, member C |
| NCBI Official Symbol: | FAM3C�� |
| NCBI Official Synonym Symbols: | ILEI; GS3786�� |
| NCBI Protein Information: | protein FAM3C; interleukin-like EMT inducer; predicted osteoblast protein; interleukin-like epithelial-mesenchymal transition inducer |
| UniProt Protein Name: | Protein FAM3C |
| UniProt Synonym Protein Names: | Interleukin-like EMT inducer |
| Protein Family: | Protein |
| UniProt Gene Name: | FAM3C�� |
| UniProt Entry Name: | FAM3C_HUMAN |
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