Human FAM3A Recombinant Protein (RPPB3508)
- SKU:
- RPPB3508
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P98173
Description
| Product Name: | Human FAM3A Recombinant Protein |
| Product Code: | RPPB3508 |
| Size: | 10µg |
| Species: | Human |
| Target: | FAM3A |
| Synonyms: | Protein FAM3A, Cytokine-like protein 2-19, FAM3A, 2-19, 2.19, DLD, XAP-7, DXS560S. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | FAM3A filtered (0.4 �m) and lyophilized from 0.5mg/ml in 20mM TRIS and 50mM NaCl, pH 7.5. |
| Solubility: | It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. FAM3A is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHASFPRIQQLFTS PESSVTAAPR ARKYKCGLPQ PCPEEHLAFR VVSGAANVIG PKICLEDKML MSSVKDNVGR GLNIALVNGV SGELIEARAF DMWAGDVNDL LKFIRPLHEG TLVFVASYDD PATKMNEETR KLFSELGSRN AKELAFRDSW VFVGAKGVQN KSPFEQHVKN SKHSNKYEGW PEALEMEGCI PRRSTAS |
Family with Sequence Similarity 3, Member A (FAM3A) is a member of the FAM3 family along with FAM3B (Pander) protein which induces apoptosis of pancreatic alpha and beta cells. FAM3A is a cytokine-like protein, which is expressed in almost all tissues such as the testis, pancreas, adrenal, placenta, brain, fetal brain, liver, kidney, skeletal muscle and the heart. FAM3A gene expression may be regulated by peroxisome proliferator-activated receptor gamma, and the FAM3A protein might be involved in the regulation of glucose and lipid metabolism. Although the function of the FAM3A protein has been unclear until now, it may act as a defensin against invading fungal microorganisms.
FAM3A Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 207 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 23.1kDa (calculated).
| UniProt Protein Function: | FAM3A: May act as a defensin against invading fungal microorganisms. Belongs to the FAM3 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: Xq28 Cellular Component: extracellular region |
| NCBI Summary: | This gene encodes a cytokine-like protein. The expression of this gene may be regulated by peroxisome proliferator-activated receptor gamma, and the encoded protein may be involved in the regulation of glucose and lipid metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | P98173 |
| NCBI GenInfo Identifier: | 118572645 |
| NCBI Gene ID: | 60343 |
| NCBI Accession: | P98173.2 |
| UniProt Related Accession: | P98173 |
| Molecular Weight: | |
| NCBI Full Name: | Protein FAM3A |
| NCBI Synonym Full Names: | family with sequence similarity 3 member A |
| NCBI Official Symbol: | FAM3A�� |
| NCBI Official Synonym Symbols: | DLD; 2.19; XAP-7; DXS560S�� |
| NCBI Protein Information: | protein FAM3A |
| UniProt Protein Name: | Protein FAM3A |
| UniProt Synonym Protein Names: | Cytokine-like protein 2-19 |
| Protein Family: | Protein |
| UniProt Gene Name: | FAM3A�� |
| UniProt Entry Name: | FAM3A_HUMAN |
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