Human FABP3 Recombinant Protein (RPPB3496)
- SKU:
- RPPB3496
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P05413
Description
| Product Name: | Human FABP3 Recombinant Protein |
| Product Code: | RPPB3496 |
| Size: | 25µg |
| Species: | Human |
| Target: | FABP3 |
| Synonyms: | Fatty acid-binding protein heart, H-FABP, Heart-type fatty acid-binding protein, Muscle fatty acid-binding protein, M-FABP, Mammary-derived growth inhibitor, MDGI, FABP3, FABP11, O-FABP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless liquid formulation. |
| Formulation: | FABP3 His-Tag is supplied in 20mM Tris-HCl pH 8.0 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
Recombinant Fatty Acid Binding Protein is a newly introduced plasma marker of acute myocardial infarction (AMI). The plasma kinetics of FABP (15kD) closely resemble those of myoglobin in that elevated plasma concentrations are found within 2 hours after AMI and return to normal generally within 18 to 24 hours. But the concentration of FABP in the skeletal muscle is 20 times lower than in cardiac tissue (for myoglobin the same content for cardiac and skeletal tissue), that makes FABP to be more cardiac specific than myoglobin. This makes FABP a useful biochemical marker for the early assessment or exclusion of AMI. FABP also appears to be a useful plasma marker for the estimation of myocardial infarct size.
FABP3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 133 amino acids and having a molecular mass of 19.1 kDa. FABP3 is fused to a 37 amino acid His tag at N-terminus and purified by standard chromatography techniques.
| UniProt Protein Function: | FABP3: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. |
| UniProt Protein Details: | Protein type:Lipid-binding Chromosomal Location of Human Ortholog: 1p33-p32 Cellular Component: extracellular space; sarcoplasm; cytosol Molecular Function:protein binding; icosatetraenoic acid binding; cytoskeletal protein binding; long-chain fatty acid transporter activity Biological Process: response to drug; negative regulation of cell proliferation; cholesterol homeostasis; regulation of fatty acid oxidation; fatty acid metabolic process; response to insulin stimulus; phospholipid homeostasis |
| NCBI Summary: | The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Code: | P05413 |
| NCBI GenInfo Identifier: | 119802 |
| NCBI Gene ID: | 2170 |
| NCBI Accession: | P05413.4 |
| UniProt Related Accession: | P05413 |
| Molecular Weight: | 14858 |
| NCBI Full Name: | Fatty acid-binding protein, heart |
| NCBI Synonym Full Names: | fatty acid binding protein 3 |
| NCBI Official Symbol: | FABP3�� |
| NCBI Official Synonym Symbols: | MDGI; FABP11; H-FABP; M-FABP; O-FABP�� |
| NCBI Protein Information: | fatty acid-binding protein, heart |
| UniProt Protein Name: | Fatty acid-binding protein, heart |
| UniProt Synonym Protein Names: | Fatty acid-binding protein 3; Heart-type fatty acid-binding protein; H-FABP; Mammary-derived growth inhibitor; MDGI; Muscle fatty acid-binding protein; M-FABP |
| Protein Family: | Fatty acid-binding protein |
| UniProt Gene Name: | FABP3�� |
| UniProt Entry Name: | FABPH_HUMAN |
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