Human Esterase D Recombinant Protein (RPPB1627)
- SKU:
- RPPB1627
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P10768
- Research Area:
- Enzymes
Description
| Product Name: | Human Esterase D Recombinant Protein |
| Product Code: | RPPB1627 |
| Size: | 50µg |
| Species: | Human |
| Target: | Esterase D |
| Synonyms: | S-formylglutathione hydrolase, FGH, Esterase D, ESD, FLJ11763, esterase D/formylglutathione hydrolase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The Esterase-D solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MALKQISSNK CFGGLQKVFE HDSVELNCKM KFAVYLPPKA ETGKCPALYW LSGLTCTEQN FISKSGYHQS ASEHGLVVIA PDTSPRGCNI KGEDESWDFG TGAGFYVDAT EDPWKTNYRM YSYVTEELPQ LINANFPVDP QRMSIFGHSM GGHGALICAL KNPGKYKSVS AFAPICNPVL CPWGKKAFSG YLGTDQSKWK AYDATHLVKS YPGSQLDILI DQGKDDQFLL DGQLLPDNFI AACTEKKIPV VFRLQEDYDH SYYFIATFIT DHIRHHAKYL NA |
Formylglutathione hydrolase (Esterase D) is a member of the esterase D family. Esterase D is a serine hydrolase involved in the detoxification of formaldehyde. Esterase D is active toward various substrates including O-acetylated sialic acids, and it may possibly be involved in the recycling of sialic acids. Esterase D is used as a genetic marker for retinoblastoma and Wilson's disease.
Esterase-D Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 302 amino acids (1-282 a.a.) and having a molecular mass of 33.6kDa.The Esterase-D is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | esterase D: an enzyme that catalyzes the conversion of carboxylic esters and H2O into alcohol and a carboxylic anion. |
| UniProt Protein Details: | Protein type:EC 3.1.2.12; EC 3.1.1.56; Hydrolase Chromosomal Location of Human Ortholog: 13q14.1-q14.2 Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane Molecular Function:S-formylglutathione hydrolase activity; methylumbelliferyl-acetate deacetylase activity; hydrolase activity, acting on ester bonds Biological Process: formaldehyde catabolic process |
| NCBI Summary: | This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a genetic marker for retinoblastoma and Wilson's disease. [provided by RefSeq, Feb 2009] |
| UniProt Code: | P10768 |
| NCBI GenInfo Identifier: | 544254 |
| NCBI Gene ID: | 2098 |
| NCBI Accession: | P10768.2 |
| UniProt Secondary Accession: | P10768,Q5TBU8, Q5TBV0, Q5TBV2, Q9BVJ2, |
| UniProt Related Accession: | P10768 |
| Molecular Weight: | 282 |
| NCBI Full Name: | S-formylglutathione hydrolase |
| NCBI Synonym Full Names: | esterase D |
| NCBI Official Symbol: | ESD�� |
| NCBI Official Synonym Symbols: | FGH�� |
| NCBI Protein Information: | S-formylglutathione hydrolase; esterase 10; esterase D/formylglutathione hydrolase; methylumbelliferyl-acetate deacetylase |
| UniProt Protein Name: | S-formylglutathione hydrolase |
| UniProt Synonym Protein Names: | Esterase D; Methylumbelliferyl-acetate deacetylase (EC:3.1.1.56) |
| UniProt Gene Name: | ESD�� |
| UniProt Entry Name: | ESTD_HUMAN |
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