Human ESM1 Recombinant Protein (RPPB3468)
- SKU:
- RPPB3468
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NQ30
Description
| Product Name: | Human ESM1 Recombinant Protein |
| Product Code: | RPPB3468 |
| Size: | 10µg |
| Species: | Human |
| Target: | ESM1 |
| Synonyms: | Endothelial cell-specific molecule 1, ESM-1, ESM1, endocan.� |
| Source: | HEK293 Cells |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | ESM1 filtered (0.4 �m) and lyophilized from 0.5mg/ml in phosphate buffered saline. |
| Solubility: | It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. ESM1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | WSNNYAVDCP QHCDSSECKS SPRCKRTVLD DCGCCRVCAA GRGETCYRTV SGMDGMKCGP GLRCQPSNGE DPFGEEFGIC KDCPYGTFGM DCRETCNCQS GICDRGTGKC LKFPFFQYSV TKSSNRFVSL TEHDMASGDG NIVREEVVKE NAAGSPVMRK WLNPR HHHHH HHHHH |
Endothelial cell-specific molecule 1 (ESM1) is a proteoglycan secreted by endothelial cells (mostly in the human lung and kidney tissues) and its mRNA expression is regulated by inflammatory cytokines. ESM1 has potent implications in lung endothelial cell-leukocyte interactions. In addition, ESM1 expression is detected in various epithelia and in adipocytes. ESM1 is involved in angiogenesis and it also promotes angiogenic sprouting. ESM1 expression is upregulated by TNF alpha, IL1 beta, or lipopolysaccharide and downregulated by IFN gamma. Genetically engineered cells overexpressing ESM1 induce tumor formation, implying that ESM1 might be involved in the pathophysiology of tumor growth in vivo.
ESM1 Human Recombinant produced in HEK293 cells is a single, glycosylated polypeptide chain (a.a 20-184) containing 175 amino acids including a 10 a.a C-terminal His tag. The total molecular mass is 46.0kDa (calculated).�
| UniProt Protein Function: | ESM1: May have potent implications in lung endothelial cell- leukocyte interactions. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5q11.2 Cellular Component: extracellular region Molecular Function:integrin binding; insulin-like growth factor binding; hepatocyte growth factor receptor binding Biological Process: positive regulation of cell proliferation; sprouting angiogenesis; regulation of cell growth; angiogenesis |
| NCBI Summary: | This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q9NQ30 |
| NCBI GenInfo Identifier: | 13431509 |
| NCBI Gene ID: | 11082 |
| NCBI Accession: | Q9NQ30.2 |
| UniProt Secondary Accession: | Q9NQ30,Q15330, Q3V4E3, Q96ES3, B2R4G3, |
| UniProt Related Accession: | Q9NQ30 |
| Molecular Weight: | 14,513 Da |
| NCBI Full Name: | Endothelial cell-specific molecule 1 |
| NCBI Synonym Full Names: | endothelial cell-specific molecule 1 |
| NCBI Official Symbol: | ESM1�� |
| NCBI Official Synonym Symbols: | endocan�� |
| NCBI Protein Information: | endothelial cell-specific molecule 1; ESM-1 |
| UniProt Protein Name: | Endothelial cell-specific molecule 1 |
| Protein Family: | Endothelial cell-specific molecule |
| UniProt Gene Name: | ESM1�� |
| UniProt Entry Name: | ESM1_HUMAN |
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