Human ESM1 Recombinant Protein (RPPB3467)
- SKU:
- RPPB3467
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NQ30
Description
| Product Name: | Human ESM1 Recombinant Protein |
| Product Code: | RPPB3467 |
| Size: | 20µg |
| Species: | Human |
| Target: | ESM1 |
| Synonyms: | Endothelial cell-specific molecule 1, ESM-1, ESM1, endocan. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ESM1 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSWSNNYAV DCPQHCDSSE CKSSPRCKRT VLDDCGCCRV CAAGRGETCY RTVSGMDGMK CGPGLRCQPS NGEDPFGEEF GICKDCPYGT FGMDCRETCN CQSGICDRGT GKCLKFPFFQ YSVTKSSNRF VSLTEHDMAS GDGNIVREEV VKENAAGSPV MRKWLNPR |
Endothelial cell-specific molecule 1 (ESM1) is a proteoglycan secreted by endothelial cells (mostly in the human lung and kidney tissues) and its mRNA expression is regulated by inflammatory cytokines. ESM1 has potent implications in lung endothelial cell-leukocyte interactions. In addition, ESM1 expression is detected in various epithelia and in adipocytes. ESM1 is involved in angiogenesis and it also promotes angiogenic sprouting. ESM1 expression is upregulated by TNF alpha, IL1 beta, or lipopolysaccharide and downregulated by IFN gamma. Genetically engineered cells overexpressing ESM1 induce tumor formation, implying that ESM1 might be involved in the pathophysiology of tumor growth in vivo.
ESM1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 188 amino acids (20-184 a.a.) and having a molecular mass of 20.5kDa.ESM1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ESM1: May have potent implications in lung endothelial cell- leukocyte interactions. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5q11.2 Cellular Component: extracellular region Molecular Function:integrin binding; insulin-like growth factor binding; hepatocyte growth factor receptor binding Biological Process: positive regulation of cell proliferation; sprouting angiogenesis; regulation of cell growth; angiogenesis |
| NCBI Summary: | This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q9NQ30 |
| NCBI GenInfo Identifier: | 13431509 |
| NCBI Gene ID: | 11082 |
| NCBI Accession: | Q9NQ30.2 |
| UniProt Secondary Accession: | Q9NQ30,Q15330, Q3V4E3, Q96ES3, B2R4G3, |
| UniProt Related Accession: | Q9NQ30 |
| Molecular Weight: | 14,513 Da |
| NCBI Full Name: | Endothelial cell-specific molecule 1 |
| NCBI Synonym Full Names: | endothelial cell-specific molecule 1 |
| NCBI Official Symbol: | ESM1�� |
| NCBI Official Synonym Symbols: | endocan�� |
| NCBI Protein Information: | endothelial cell-specific molecule 1; ESM-1 |
| UniProt Protein Name: | Endothelial cell-specific molecule 1 |
| Protein Family: | Endothelial cell-specific molecule |
| UniProt Gene Name: | ESM1�� |
| UniProt Entry Name: | ESM1_HUMAN |
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