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Human EPGN Recombinant Protein (RPPB0182)

SKU:
RPPB0182
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q6UW88
Research Area:
Growth Factors & Cytokines
$371
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Description

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Product Name:Human EPGN Recombinant Protein
Product Code:RPPB0182
Size:25µg
Species:Human
Target:EPGN
Synonyms:EPG, Epigen, PRO9904, ALGV3072, FLJ75542, EPGN, Epithelial mitogen.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:EPGN was lyophilized from 20mM PBS buffer pH-7.4 containing 130mM sodium chloride.
Solubility:It is recommended to reconstitute the lyophilized Epigen in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.�
Stability:Lyophilized Epigen although stable at room temperature for 3 weeks, should be stored desiccated below -18?C. Upon reconstitution EPGN should be stored at 4?C between 2-7 days and for future use below -18?C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Amino Acid Sequence:AVTVTPPITA QQADNIEGPI ALKFSHLCLE DHNSYCINGA CAFHHELEKA ICRCFTGYTG ERCEHLTLTS YA

EPGN is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. EPGN is produced in numerous tissues, including the testis, liver, heart and in certain tumor cells. EPGN is mitogenic for fibroblasts and epithelial cells. Human EPGN is originally synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence.

Epigen Recombinant Human produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 72 amino acids and having a molecular mass of 7.9 kDa. Epigen is purified by proprietary chromatographic techniques.

UniProt Protein Function:Epigen: Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinaseChromosomal Location of Human Ortholog: 4q13.3Cellular Component: extracellular space; integral to plasma membrane; intracellularMolecular Function: epidermal growth factor receptor binding; growth factor activityBiological Process: activation of MAPK activity; angiogenesis; epidermal growth factor receptor signaling pathway; MAPKKK cascade; positive regulation of cell proliferation; positive regulation of epidermal growth factor receptor activity; positive regulation of epithelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of mitosis
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Code:Q6UW88
NCBI GenInfo Identifier:229464464
NCBI Gene ID:255324
NCBI Accession:Q6UW88.2
UniProt Secondary Accession:Q6UW88,A1BMM3, A1BMM4, A1BMM5, A1BMM6, A1BMM7, A1BMM8 A8K090
UniProt Related Accession:Q6UW88
Molecular Weight:
NCBI Full Name:Epigen
NCBI Synonym Full Names:epithelial mitogen
NCBI Official Symbol:EPGN��
NCBI Official Synonym Symbols:EPG; PRO9904; ALGV3072��
NCBI Protein Information:epigen
UniProt Protein Name:Epigen
UniProt Synonym Protein Names:Epithelial mitogen; EPG
Protein Family:Epigen
UniProt Gene Name:EPGN��
UniProt Entry Name:EPGN_HUMAN

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