Human ENTPD3 Recombinant Protein (RPPB1623)
- SKU:
- RPPB1623
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O75355
- Research Area:
- Enzymes
Description
| Product Name: | Human ENTPD3 Recombinant Protein |
| Product Code: | RPPB1623 |
| Size: | 4µg |
| Species: | Human |
| Target: | ENTPD3 |
| Synonyms: | EctonucleosideTriphosphate Diphosphohydrolase 3, Ecto-ATP Diphosphohydrolase 3, CD39Antigen-Like 3, Ecto-ATPDase 3, Ecto-Apyrase 3, Ecto-ATPase 3, EC 3.6.1.5, NTPDase3, CD39L3, HB6, NTPDase-3, EC 3.6.1, Ectonucleoside triphosphatediphosphohydrolase 3, NTPDase 3, CD39 antigen-like 3, Ecto-ATPdiphosphohydrolase 3, Ecto-ATPDase 3, Ecto-ATPase 3, Ecto-apyrase 3, HB6. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ENTPD3 protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADLQIHKQEV LPPGLKYGIVLDAGSSRTTV YVYQWPAEKE NNTGVVSQTF KCSVKGSGIS SYGNNPQDVP RAFEECMQKV KGQVPSHLHG STPIHLGATAGMRLLRLQNE TAANEVLESI QSYFKSQPFD FRGAQIISGQ EEGVYGWITA NYLMGNFLEK NLWHMWVHPHGVETTGALDLGGASTQISFV AGEKMDLNTS DIMQVSLYGY VYTLYTHSFQ CYGRNEAEKKFLAMLLQNSP TKNHLTNPCY PRDYSISFTM GHVFDSLCTV DQRPESYNPN DVITFEGTGD PSLCKEKVASIFDFKACHDQ ETCSFDGVYQ PKIKGPFVAF AGFYYTASAL NLSGSFSLDT FNSSTWNFCSQNWSQLPLLL PKFDEVYARSYCFSANYIYH LFVNGYKFTE ETWPQIHFEK EVGNSSIAWS LGYMLSLTNQ IPAESPLIRL PIEPPHHHHHH |
| Biological Activity: | Specificactivity is > 250,000 pmol/min/ug, and is defined as the amount of enzymethat hydrolyze ATP per minute at pH 7.5 at 37C. |
Ectonucleoside Triphosphate Diphosphohydrolase 3, also known as ENTPD3, which owns a threefold preference for the hydrolysis of ATP over ADP is similar to E-type nucleotidases (NTPases). ENTPD3 is a protein coding gene which contains four apyrase-conserved areas which is characteristic of NTPases.
ENTPD3 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 451 amino acids (44-485a.a.) and having a molecular mass of 50.7kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).ENTPD3 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ENTPD3: Has a threefold preference for the hydrolysis of ATP over ADP. Belongs to the GDA1/CD39 NTPase family. |
| UniProt Protein Details: | Protein type:Hydrolase; EC 3.6.1.5; Membrane protein, integral; Phosphatase (non-protein); Nucleotide Metabolism - purine; Membrane protein, multi-pass; Nucleotide Metabolism - pyrimidine Chromosomal Location of Human Ortholog: 3p21.3 Molecular Function:protein binding |
| NCBI Summary: | This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014] |
| UniProt Code: | O75355 |
| NCBI GenInfo Identifier: | 115311595 |
| NCBI Gene ID: | 956 |
| NCBI Accession: | O75355.2 |
| UniProt Secondary Accession: | O75355,O60495, Q8N6K2, B2R8D0, G5E9N0, |
| UniProt Related Accession: | O75355 |
| Molecular Weight: | 50,762 Da |
| NCBI Full Name: | Ectonucleoside triphosphate diphosphohydrolase 3 |
| NCBI Synonym Full Names: | ectonucleoside triphosphate diphosphohydrolase 3 |
| NCBI Official Symbol: | ENTPD3�� |
| NCBI Official Synonym Symbols: | HB6; CD39L3; NTPDase-3�� |
| NCBI Protein Information: | ectonucleoside triphosphate diphosphohydrolase 3 |
| UniProt Protein Name: | Ectonucleoside triphosphate diphosphohydrolase 3 |
| UniProt Synonym Protein Names: | CD39 antigen-like 3; Ecto-ATP diphosphohydrolase 3; Ecto-ATPDase 3; Ecto-ATPase 3; Ecto-apyrase 3; HB6 |
| Protein Family: | Ectonucleoside triphosphate diphosphohydrolase |
| UniProt Gene Name: | ENTPD3�� |
| UniProt Entry Name: | ENTP3_HUMAN |
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