Human Enterokinase Recombinant Protein (RPPB1620)
- SKU:
- RPPB1620
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P98073
- Research Area:
- Enzymes
Description
| Product Name: | Human Enterokinase Recombinant Protein |
| Product Code: | RPPB1620 |
| Size: | 20µg |
| Species: | Human |
| Target: | Enterokinase |
| Synonyms: | Enteropeptidase, EC 3.4.21.9, Enterokinase, Serine protease 7, ENTK,TMPRSS15, MGC133046, Transmembrane Protease Serine 15. |
| Source: | Escherichia Coli |
| Physical Appearance: | Liquid solution. |
| Formulation: | Enterokinase 1mg/ml is supplied in 20mM Tris-HCl, pH 8.0, and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MAIVGGSNAK EGAWPWVVGL YYGGRLLCGA SLVSSDWLVS AAHCVYGRNL EPSKWTAILG LHMKSNLTSP QTVPRLIDEI�VINPHYNRRR KDNDIAMMHL EFKVNYTDYI QPICLPEENQ VFPPGRNCSI AGWGTVVYQG TTANILQEAD VPLLSNERCQ�QQMPEYNITE NMICAGYEEG GIDSCQGDSG GPLMCQENNR WFLAGVTSFG YKCALPNRPG VYARVSRFTE WIQSFLH |
Enteropeptidase or enterokinase is an enzymeinvolved in human digestion. It is produced by cells in the duodenum wall, and is secreted from duodenum's glands, the crypts of Lieberkuhn, whenever ingested food enters the duodenum from the stomach. Enteropeptidase has the critical job of turning trypsinogen(a zymogen) to trypsin, indirectly activating a number of pancreaticdigestive enzymes.Enteropeptidase is a serine proteaseenzyme(EC3.4.21.9). Enteropeptidase is a part of the Chymotrypsin-clan of serine proteases, and is structurally similar to these proteins.
Enterokinase Human produced in E.Coli�cells is a single, non-glycosylated polypeptide chain containing 237 amino acids (785-1019aa ) and having a molecular mass of 26.4kDa. Enterokinase is purified by proprietary chromatographic techniques
| UniProt Protein Function: | PRSS7: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. Defects in TMPRSS15 are a cause of enterokinase deficiency (ENTKD); a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive. Belongs to the peptidase S1 family. |
| UniProt Protein Details: | Protein type:EC 3.4.21.9; Membrane protein, integral; Protease Chromosomal Location of Human Ortholog: 21q21.1 Cellular Component: brush border Molecular Function:protein binding Disease: Enterokinase Deficiency |
| NCBI Summary: | This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P98073 |
| NCBI GenInfo Identifier: | 317373442 |
| NCBI Gene ID: | 5651 |
| NCBI Accession: | P98073.3 |
| UniProt Secondary Accession: | P98073,Q2NKL7, |
| UniProt Related Accession: | P98073 |
| Molecular Weight: | Calculated MW: 112kDaObserved MW: 113kDa |
| NCBI Full Name: | Enteropeptidase |
| NCBI Synonym Full Names: | transmembrane protease, serine 15 |
| NCBI Official Symbol: | TMPRSS15�� |
| NCBI Official Synonym Symbols: | ENTK; PRSS7�� |
| NCBI Protein Information: | enteropeptidase |
| UniProt Protein Name: | Enteropeptidase |
| UniProt Synonym Protein Names: | Enterokinase; Serine protease 7; Transmembrane protease serine 15 |
| Protein Family: | Enteropeptidase |
| UniProt Gene Name: | TMPRSS15�� |
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