Human ENSA Recombinant Protein (RPPB3449)
- SKU:
- RPPB3449
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O43768
Description
| Product Name: | Human ENSA Recombinant Protein |
| Product Code: | RPPB3449 |
| Size: | 25µg |
| Species: | Human |
| Target: | ENSA |
| Synonyms: | ARPP-19e, Alpha endosulfine isoform 3, Alpha-endosulfine, ENSA, MGC4319, MGC8394, MGC78563. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The Endosulfine Alpha protein solution contains 20mM Tris, pH-8, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV E |
ENSA is an endogenous ligand for sulfonylurea receptor. ENSA reduces K(ATP) channel currents by inhibiting sulfonylurea from binding to the receptor and thus stimulates insulin secretion. Endosulfine Alpha is part of a conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine Alpha is an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. Endosulfine Alpha is an endogenous regulator of KATP channels. ENSA modulates insulin secretion through the interaction with KATP channel. ENSA is a candidate gene for type 2 diabetes. ENSA is expressed in a wide range of tissues including muscle, brain, and endocrine tissues.
ENSA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 141 amino acids (1-121 a.a.) and having a molecular weight of 15.5kDa. The ENSA is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ENSA: a cytoplasmic, highly conserved cAMP-regulated phosphoprotein (ARPP) and regulator of ATP-sensitive potassium (KATP) channels. An endogenous ligand for the sulfonylurea receptor, ABCC8, the regulatory subunit of the KATP channel located on the plasma membrane of pancreatic beta cells. Modulates insulin secretion through the interaction with ABCC8, and may be associated with type 2 diabetes. Eight alternatively spliced isoforms have been observed. |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: nucleoplasm; cytoplasm Molecular Function:phosphatase inhibitor activity; protein phosphatase 2A binding; protein phosphatase type 2A regulator activity; protein phosphatase inhibitor activity; potassium channel inhibitor activity; ion channel inhibitor activity; receptor binding Biological Process: mitosis; transport; regulation of catalytic activity; cell division; negative regulation of catalytic activity; response to glucose stimulus; mitotic cell cycle; G2/M transition of mitotic cell cycle; regulation of insulin secretion; response to nutrient |
| NCBI Summary: | The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43768 |
| NCBI GenInfo Identifier: | 2764974 |
| NCBI Gene ID: | 2029 |
| NCBI Accession: | CAA68180.1 |
| UniProt Secondary Accession: | O43768,Q5T5H2, Q68D48, Q6FHW0, Q6IAM4, Q6NUL2, Q6VUC6 Q6VUC7, Q6VUC8, Q6VUC9, A8K1Z9, E9PB69, |
| UniProt Related Accession: | O43768 |
| Molecular Weight: | 14,868 Da |
| NCBI Full Name: | alpha endosulfine |
| NCBI Synonym Full Names: | endosulfine alpha |
| NCBI Official Symbol: | ENSA�� |
| NCBI Official Synonym Symbols: | ARPP-19e�� |
| NCBI Protein Information: | alpha-endosulfine |
| UniProt Protein Name: | Alpha-endosulfine |
| UniProt Synonym Protein Names: | ARPP-19e |
| Protein Family: | Alpha-endosulfine |
| UniProt Gene Name: | ENSA�� |
| UniProt Entry Name: | ENSA_HUMAN |
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