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Human EIF4EBP3 Recombinant Protein (RPPB3435)

SKU:
RPPB3435
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O60516
€469
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Description

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Product Name:Human EIF4EBP3 Recombinant Protein
Product Code:RPPB3435
Size:10µg
Species:Human
Target:EIF4EBP3
Synonyms:Eukaryotic translation initiation factor 4E-binding protein 3, 4E-BP3, eIF4E-binding protein 3, EIF4EBP3, 4EBP3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The EIF4EBP3 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSTSTSC PIPGGRDQLP DCYSTTPGGT LYATTPGGTR IIYDRKFLLE CKNSPIARTP PCCLPQIPGV TTPPTAPLSK LEELKEQETE EEIPDDAQFE MDI

Eukaryotic Translation Initiation Factor 4E-Binding Protein 3 (EIF4EBP3) belongs to the EIF4EBP family whose proteins bind to eukaryotic initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that identifies the mRNA cap structure.

EIF4EBP3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 123 amino acids (1-100) and having a molecular mass of 13.3 kDa.EIF4EBP3 is fused to a 23 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:4E-BP3: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. EIF4EBP3 interacts with EIF4E. Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus. Belongs to the eIF4E-binding protein family.
UniProt Protein Details:

Protein type:Translation; Translation initiation

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: cytoplasm; membrane

Molecular Function:eukaryotic initiation factor 4E binding; protein binding

Biological Process: negative regulation of translational initiation

NCBI Summary:This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]
UniProt Code:O60516
NCBI GenInfo Identifier:4503537
NCBI Gene ID:8637
NCBI Accession:NP_003723.1
UniProt Related Accession:O60516
Molecular Weight:26.87kD
NCBI Full Name:eukaryotic translation initiation factor 4E-binding protein 3
NCBI Synonym Full Names:eukaryotic translation initiation factor 4E binding protein 3
NCBI Official Symbol:EIF4EBP3��
NCBI Official Synonym Symbols:4EBP3; 4E-BP3��
NCBI Protein Information:eukaryotic translation initiation factor 4E-binding protein 3
UniProt Protein Name:Eukaryotic translation initiation factor 4E-binding protein 3
Protein Family:Eukaryotic translation initiation factor 4E-binding protein
UniProt Gene Name:EIF4EBP3��

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