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Nanodisc Human EDNRA-Strep Protein (HDFP962)

SKU:
HDFP962
Size:
10μg
Target:
EDNRA
Tag:
C-Flag&Strep Tag
Expression Host:
HEK293
Conjugate:
Unconjugated
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Description

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Product Name:Nanodisc Human EDNRA-Strep Protein
SKU:HDFP962
Size:10μg
Target:EDNRA
Tag:C-Flag&Strep Tag
Expression Host:HEK293
Conjugate:Unconjugated
Synonyms:ET-A, ETA, ETA-R, ETAR, ETRA, MFDA, hET-AR
Protein Families:GPCR, Transmembrane, Druggable Genome.
Protein Description:Human EDNRA-Strep full length protein-synthetic nanodisc
Protein Pathways:GPCRDB Class A Rhodopsin-like, GPCRDB Other, Peptide GPCRs, Prostaglandin synthesis regulation, Angiogenesis, Cancer, Endothelial Cell Biology.
Molecular Weight:The human full length EDNRA-Strep protein has a MW of 48.7 kDa

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Uniprot ID:P25101
Formulation & Reconstitution:Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping:Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Usage:Research use only

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