Nanodisc Human EDNRA Protein (HDFP225)
- SKU:
- HDFP225
- Size:
- 10μg
- Target:
- EDNRA
- Tag:
- C-Flag Tag
- Expression Host:
- HEK293
- Conjugate:
- Unconjugated
Frequently bought together:
Description
| Product Name: | Nanodisc Human EDNRA Protein |
| SKU: | HDFP225 |
| Size: | 10μg |
| Target: | EDNRA |
| Tag: | C-Flag Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | ET-A, ETA, ETA-R, ETAR, ETRA, MFDA, hET-AR |
| Protein Families: | GPCR, Transmembrane, Druggable Genome. |
| Protein Description: | Human EDNRA full length protein-synthetic nanodisc |
| Protein Pathways: | GPCRDB Class A Rhodopsin-like, GPCRDB Other, Peptide GPCRs, Prostaglandin synthesis regulation, Angiogenesis, Cancer, Endothelial Cell Biology. |
| Molecular Weight: | The human full length EDNRA protein has a MW of 48.7kDa |
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
| Uniprot ID: | P25101 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
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