Human DUSP19 Recombinant Protein (RPPB1595)
- SKU:
- RPPB1595
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8WTR2
- Research Area:
- Enzymes
Description
| Product Name: | Human DUSP19 Recombinant Protein |
| Product Code: | RPPB1595 |
| Size: | 10µg |
| Species: | Human |
| Target: | DUSP19 |
| Synonyms: | Dual specificity protein phosphatase 19, Dual specificity phosphatase TS-DSP1, Low molecular weight dual specificity phosphatase 3, LMW-DSP3, Protein phosphatase, SKRP1, Stress-activated protein kinase pathway-regulating phosphatase 1, SAPK pathway-regulating phosphatase 1, DUSP19, DUSP17, LMWDSP3, TS-DSP1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The DUSP19 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 30% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSQVGVIKP WLLLGSQDAA HDLDTLKKNK VTHILNVAYG VENAFLSDFT YKSISILDLP ETNILSYFPE CFEFIEEAKR KDGVVLVHCN AGVSRAAAIV IGFLMNSEQT SFTSAFSLVK NARPSICPNS GFMEQLRTYQ EGKESNKCDR IQENSS |
DUSPs are distinguished by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSPs have been implicated as major modulators of critical signaling pathways. Dual specificity phosphatase 19 (DUSP19) belongs to the dual specificity protein phosphatase subfamily. DUSP19 is a protein phosphatase which functions as a stress-activated protein kinase pathway-regulating phosphatase. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP class of DUSPs.
DUSP19 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 176 amino acids (65-217) and having a molecular mass of 19.4kDa.DUSP19 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DUSP19: Has a dual specificity toward Ser/Thr and Tyr-containing proteins. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q32.1 Cellular Component: cytoplasm Molecular Function:protein tyrosine/threonine phosphatase activity; JUN kinase phosphatase activity; MAP-kinase scaffold activity; protein kinase inhibitor activity; protein tyrosine phosphatase activity; mitogen-activated protein kinase kinase kinase binding; protein kinase activator activity Biological Process: negative regulation of JNK activity; negative regulation of JNK cascade; positive regulation of JNK activity; positive regulation of MAPKKK cascade; positive regulation of protein kinase activity; JNK cascade; positive regulation of JNK cascade; negative regulation of protein kinase activity; protein amino acid dephosphorylation; inactivation of MAPK activity |
| NCBI Summary: | Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009] |
| UniProt Code: | Q8WTR2 |
| NCBI GenInfo Identifier: | 29840769 |
| NCBI Gene ID: | 142679 |
| NCBI Accession: | Q8WTR2.1 |
| UniProt Secondary Accession: | Q8WTR2,Q547H4, Q8WYN4, B2RA79, |
| UniProt Related Accession: | Q8WTR2 |
| Molecular Weight: | 217 |
| NCBI Full Name: | Dual specificity protein phosphatase 19 |
| NCBI Synonym Full Names: | dual specificity phosphatase 19 |
| NCBI Official Symbol: | DUSP19�� |
| NCBI Official Synonym Symbols: | SKRP1; DUSP17; LMWDSP3; TS-DSP1�� |
| NCBI Protein Information: | dual specificity protein phosphatase 19; LMW-DSP3; protein phosphatase SKRP1; dual specificity phosphatase TS-DSP1; SAPK pathway-regulating phosphatase 1; low molecular weight dual specificity phosphatase 3; stress-activated protein kinase pathway-regulating phosphatase 1 |
| UniProt Protein Name: | Dual specificity protein phosphatase 19 |
| UniProt Synonym Protein Names: | Dual specificity phosphatase TS-DSP1; Low molecular weight dual specificity phosphatase 3; LMW-DSP3; Protein phosphatase SKRP1; Stress-activated protein kinase pathway-regulating phosphatase 1; SAPK pathway-regulating phosphatase 1 |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP19�� |
| UniProt Entry Name: | DUS19_HUMAN |
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