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Human DNAJB8 Recombinant Protein (RPPB5204)

SKU:
RPPB5204
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8NHS0
€309
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Description

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Product Name:Human DNAJB8 Recombinant Protein
Product Code:RPPB5204
Size:25µg
Species:Human
Target:DNAJB8
Synonyms:DnaJ homolog subfamily B member 8, DNAJB8, DJ6.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The DNAJB8 solution (0.25mg/ml) 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.15M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MANYYEVLGV QASASPEDIK KAYRKLALRW HPDKNPDNKE EAEKKFKLVS EAYEVLSDSK KRSLYDRAGC DSWRAGGGAS TPYHSPFDTG YTFRNPEDIF REFFGGLDPF SFEFWDSPFN SDRGGRGHGL RGAFSAGFGE FPAFMEAFSS FNMLGCSGGS HTTFSSTSFG GSSSGSSGFK SVMSSTEMIN GHKVTTKRIV ENGQERVEVE EDGQLKSVTV NGKEQLKWMD SK

DnaJ homolog subfamily B member 8 (DNAJB8) is superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins.DNAJB8 is a member of the DNAJ/HSP40 family of proteins that regulate chaperone activity. DNAJB8 is (de)acetylated at 2 conserved C-terminal lysines which aren�t involved in substrate binding, but do have a role in suppressing protein aggregation. DNAJB8 has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma.

DNAJB8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (1-232 a.a.) and having a molecular mass of 27.8kDa.DNAJB8 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]
UniProt Code:Q8NHS0
NCBI GenInfo Identifier:23503241
NCBI Gene ID:165721
NCBI Accession:NP_699161.1
UniProt Secondary Accession:Q8NHS0,B3KWV7
UniProt Related Accession:Q8NHS0
Molecular Weight:25,686 Da
NCBI Full Name:dnaJ homolog subfamily B member 8
NCBI Synonym Full Names:DnaJ heat shock protein family (Hsp40) member B8
NCBI Official Symbol:DNAJB8��
NCBI Official Synonym Symbols:DJ6; CT156��
NCBI Protein Information:dnaJ homolog subfamily B member 8
UniProt Protein Name:DnaJ homolog subfamily B member 8
UniProt Synonym Protein Names:
Protein Family:
UniProt Gene Name:DNAJB8��
UniProt Entry Name:

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