Human DLK1 Recombinant Protein (RPPB3355)
- SKU:
- RPPB3355
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P80370
Description
| Product Name: | Human DLK1 Recombinant Protein |
| Product Code: | RPPB3355 |
| Size: | 10µg |
| Species: | Human |
| Target: | DLK1 |
| Synonyms: | DLK1, Delta-Like 1 Homolog (Drosophila), PREF1, DLK-1, FA1, DLK, PG2, Delta-Like Homolog (Drosophila), Protein Delta Homolog 1, Preadipocyte Factor 1, Fetal Antigen 1, Secredeltin, DELTA1, Pref-1, ZOG. |
| Source: | HEK293 Cells |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | DLK1 filtered (0.4 �m) and lyophilized from 0.5mg/ml in PBS and 5% w/v trehalose, pH7.4 |
| Solubility: | It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. DLK1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | AECFPACNPQ NGFCEDDNVC RCQPGWQGPL CDQCVTSPGC LHGLCGEPGQ CICTDGWDGE LCDRDVRACS SAPCANNRTC VSLDDGLYEC SCAPGYSGKD CQKKDGPCVI NGSPCQHGGT CVDDEGRASH ASCLCPPGFS GNFCEIVANS CTPNPCENDG VCTDIGGDFR CRCPAGFIDK TCSRPVTNCA SSPCQNGGTC LQHTQVSYEC LCKPEFTGLT CVKKRALSPQ QVTRLPSGYG LAYRLTPGVH ELPVQQPEHR ILKVSMKELN KKTPLLTEGQ HHHHHHHHHH |
Delta-Like 1, also known as DLK1 is a member of the Notch/Delta/Serrate family of epidermal growth factor (EGF)-like repeat-containing proteins which act as ligands in the Notch signaling pathway. Furthermore, DLK1 has six highly conserved epidermal-growth-factor motifs and it also contains up to ten O-glycosylation and N-glycosylation locations, six of them are differentially glycosylated.
DLK1 Human Recombinant produced in HEK293 Cells is a single, glycosylated, polypeptide chain (a.a 24-303) containing 290 amino acids including a 10 a.a C-terminal His tag. The total molecular mass is 31.2kDa (calculated).�
| UniProt Protein Function: | DLK1: May have a role in neuroendocrine differentiation. Monomer. Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 14q32 Cellular Component: extracellular space Biological Process: negative regulation of Notch signaling pathway |
| NCBI Summary: | This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015] |
| UniProt Code: | P80370 |
| NCBI GenInfo Identifier: | 296439371 |
| NCBI Gene ID: | 8788 |
| NCBI Accession: | P80370.3 |
| UniProt Secondary Accession: | P80370,P15803, Q96DW5, |
| UniProt Related Accession: | P80370 |
| Molecular Weight: | 33,067 Da |
| NCBI Full Name: | Protein delta homolog 1 |
| NCBI Synonym Full Names: | delta like non-canonical Notch ligand 1 |
| NCBI Official Symbol: | DLK1�� |
| NCBI Official Synonym Symbols: | DLK; FA1; ZOG; pG2; DLK-1; PREF1; Delta1; Pref-1�� |
| NCBI Protein Information: | protein delta homolog 1 |
| UniProt Protein Name: | Protein delta homolog 1 |
| UniProt Synonym Protein Names: | pG2 |
| Protein Family: | Protein |
| UniProt Gene Name: | DLK1�� |
| UniProt Entry Name: | DLK1_HUMAN |
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